ovarian stimulation with gonadotrophins in patients with polycystic ovary syndrome

Isnard, V.; Paillet, S.; Patin, V.; Lesourd-Pontonnier, F.; Pasquier-Pelletier, M.; Dewailly, D.

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1016/j.gofs.2018.11.009

PMID :

30573426

URL permanente :

http://hdl.handle.net/20.500.12210/40027

Titre :

ovarian stimulation with gonadotrophins in patients with polycystic ovary syndrome

Auteur(s) :

Isnard, V. [Auteur]
Paillet, S. [Auteur]
Patin, V. [Auteur]
Lesourd-Pontonnier, F. [Auteur]
Pasquier-Pelletier, M. [Auteur]
Dewailly, D. [Auteur]

Titre de la revue :

Gynecologie, obstetrique, fertilite & senologie

Nom court de la revue :

Gynecol Obstet Fertil Senol

Date de publication :

2018-12-17

ISSN :

2468-7189

Mot(s)-clé(s) :

Polycystic ovary syndrome
Gonadotrophin
Ovarian stimulation
Assisted reproductive technologies

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The main objective of this study was to describe the ovulation rate in patients with polycystic ovary syndrome, treated with ovulation induction/intra-uterine insemination and follitropin alfa by gonadotrophins at a second ...
Lire la suite >The main objective of this study was to describe the ovulation rate in patients with polycystic ovary syndrome, treated with ovulation induction/intra-uterine insemination and follitropin alfa by gonadotrophins at a second attempt. An observational, national and multicentre study was carried out: 51 French physicians (endocrinologists, gynaecologists) participated. Eligible patients were followed according to the usual clinical practices. The primary endpoint was the number of ovulations (spontaneous or triggered). Quality of life evaluation (by FertiQoL), compliance, and patient satisfaction were secondary endpoints. A total of 202 patients (mean age: 29.9 years; mean infertility: 2.9 years) were included: 78.4% met the Rotterdam definition. The ovulation rate was 93.3% (95% confidence interval [89.8; 96.8]%). At 12 weeks of gestation, 38 patients had an ongoing pregnancy. A difference of 10 points of the mean total FertiQoL score was observed between the two attempts. No patient reported missing injection. More than 9 in 10 patients said they were satisfied to very satisfied with the use of the pen injector for administration of follitropin alfa. Eight patients (4.0%) had hyperstimulation leading to cycle cancellation, and two patients (1.1%) reported ovarian hyperstimulation syndrome. At the second cycle of follitropin alfa stimulation, a high rate of ovulations, satisfactory compliance and tolerance profile associated with a change in quality of life were reported.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Développement et plasticité du cerveau neuro-endocrine

Date de dépôt :

2021-06-23T13:41:10Z

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