Fkbp5 gene variants and borderline personality disorder

Amad, Ali; Ramoz, Nicolas; Peyre, Hugo; Thomas, Pierre; Gorwood, Philip

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1016/j.jad.2019.01.025

PMID :

30711865

URL permanente :

http://hdl.handle.net/20.500.12210/40033

Titre :

Fkbp5 gene variants and borderline personality disorder

Auteur(s) :

Amad, Ali [Auteur]

415060|||Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Ramoz, Nicolas [Auteur]
Peyre, Hugo [Auteur]
Thomas, Pierre [Auteur]

Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Gorwood, Philip [Auteur]

Titre de la revue :

Journal of affective disorders

Nom court de la revue :

J Affect Disord

Numéro :

248

Pagination :

26-28

Date de publication :

2019-01-27

ISSN :

1573-2517

Mot(s)-clé(s) :

Borderline personality disorder
FKBP5
SNP
Stress axis

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Genes associated with the physiological response to stress in the hypothalamic-pituitary-adrenal axis are considered as good candidates for genetic research in borderline personality disorder (BPD). Methods In ...
Lire la suite >Background Genes associated with the physiological response to stress in the hypothalamic-pituitary-adrenal axis are considered as good candidates for genetic research in borderline personality disorder (BPD). Methods In this study, five FKBP5 (a co-chaperone of the glucocorticoid receptor) SNPs (rs3800373, rs9296158, rs737054, rs1360780, rs9470080) were genotyped in a sample of 101 unrelated Caucasian patients with BPD and 111 ethnically matched healthy controls. The interaction between FKBP5 polymorphisms and childhood trauma was also tested. Results All FKBP5 polymorphisms genotyped showed significant associations with BPD. A main effect of rs9470080 (p = 0.01) and gene x environment (physical abuse) interaction (p = 0.01) was found. A gene x environment (emotional abuse) interaction was also found for rs3800373 (p = 0.03). However, these interactions did not remain significant after multiple testing corrections. Limitations In this study, only 5 genetic variants were tested and thus tagging of the FKBP5 gene was incomplete. Moreover, the sample size is moderate. Conclusion BPD is associated with FKBP5 polymorphisms and several types of childhood abuse may modulate the effect between FKBP5 SNPs and this disorder.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Date de dépôt :

2021-06-23T13:41:12Z
2023-06-05T14:36:06Z

Numéro de version	Lien	Date de modification
2	20.500.12210/40033*	2023-06-05T14:34:58Z
1	20.500.12210/40033.1	2021-06-23T13:41:12Z

Fkbp5 gene variants and borderline personality ...

BibTeX

CSV

Excel

RIS

Historique des modifications

Fkbp5 gene variants and borderline personality ... BibTeX CSV Excel RIS

Historique des modifications

Fkbp5 gene variants and borderline personality ...

BibTeX

CSV

Excel

RIS