Experimental evidence for circular inference in schizophrenia

Jardri, Renaud; Duverne, Sandrine; Litvinova, Alexandra S.; Denève, Sophie

Document type :

Article dans une revue scientifique

DOI :

10.1038/ncomms14218

PMID :

28139642

Permalink :

http://hdl.handle.net/20.500.12210/4007

Title :

Experimental evidence for circular inference in schizophrenia

Author(s) :

Jardri, Renaud [Auteur]

Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Laboratoire de Neurosciences Cognitives & Computationnelles [LNC2]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Duverne, Sandrine [Auteur]
Laboratoire de Neurosciences Cognitives & Computationnelles [LNC2]
Litvinova, Alexandra S. [Auteur]
Lomonosov Moscow State University = Université d'État Lomonossov de Moscou [Moscou] [MSU]
Denève, Sophie [Auteur]
Laboratoire de Neurosciences Cognitives & Computationnelles [LNC2]

Journal title :

Nature communications

Volume number :

Pages :

14218

Publication date :

2017-01-31

ISSN :

2041-1723

HAL domain(s) :

Sciences cognitives

English abstract : [en]

<p>Schizophrenia is a mental disorder characterized by hallucinations and delusions. Here Schizophrenia (SCZ) is a complex mental disorder that may result in some combination ofhallucinations, delusions and disorganized ...
Show more ><p>Schizophrenia is a mental disorder characterized by hallucinations and delusions. Here Schizophrenia (SCZ) is a complex mental disorder that may result in some combination ofhallucinations, delusions and disorganized thinking. Here SCZ patients and healthy controls(CTLs) report their level of confidence on a forced-choice task that manipulated the strengthof sensory evidence and prior information. Neither group’s responses can be explained bysimple Bayesian inference. Rather, individual responses are best captured by a modelwith different degrees of circular inference. Circular inference refers to a corruption ofsensory data by prior information and vice versa, leading us to ‘see what we expect’(through descending loops), to ‘expect what we see’ (through ascending loops) or both.Ascending loops are stronger for SCZ than CTLs and correlate with the severity of positivesymptoms. Descending loops correlate with the severity of negative symptoms. Both loopscorrelate with disorganized symptoms. The findings suggest that circular inference mightmediate the clinical manifestations of SCZ.Show less >

Language :

Anglais

Audience :

Non spécifiée

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Research team(s) :

Équipe Psychiatrie & Croyance (PsyCHIC)

Submission date :

2019-02-13T14:17:58Z
2020-01-23T08:28:34Z
2020-03-23T14:21:40Z

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Except where otherwise noted, this item's license is described as Attribution 3.0 United States

Version	Link	Modification date
3	20.500.12210/4007*	2020-03-23T14:15:16Z
2	20.500.12210/4007.2	2020-01-23T08:27:42Z
1	20.500.12210/4007.1	2019-02-13T14:17:58Z

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Experimental evidence for circular inference ...

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