Non-nutritive sweeteners induce hypothalamic ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
Permalink :
Title :
Non-nutritive sweeteners induce hypothalamic er stress causing abnormal axon outgrowth
Author(s) :
Journal title :
Frontiers in Endocrinology
Abbreviated title :
Front Endocrinol (Lausanne)
Volume number :
10
Pages :
876
Publication date :
2019-01-01
ISSN :
1664-2392
Keyword(s) :
hypothalamus
aspartame
acesulfame potassium
sucralose
rebaudioside A
ER stress
development
plasticity
aspartame
acesulfame potassium
sucralose
rebaudioside A
ER stress
development
plasticity
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
With the prevalence of obesity, non-nutritive sweeteners (NNS) have been widely used as sugar substitutes as they deliver a sweet taste without excessive caloric load. However, it is increasingly recognized that NNS are ...
Show more >With the prevalence of obesity, non-nutritive sweeteners (NNS) have been widely used as sugar substitutes as they deliver a sweet taste without excessive caloric load. However, it is increasingly recognized that NNS are not inert compounds and may cause long-term metabolic perturbations. Endoplasmic reticulum (ER) stress has emerged as a critical link in the development of obesity and type 2 diabetes. In this study, we investigated the effects of NNS found in common diet beverages (i.e., sucralose, aspartame, acesulfame potassium) and a natural sweetener (i.e., rebaudioside A) on ER stress in the hypothalamic cell line mHypoE-N43/5 in vivoex vivoShow less >
Show more >With the prevalence of obesity, non-nutritive sweeteners (NNS) have been widely used as sugar substitutes as they deliver a sweet taste without excessive caloric load. However, it is increasingly recognized that NNS are not inert compounds and may cause long-term metabolic perturbations. Endoplasmic reticulum (ER) stress has emerged as a critical link in the development of obesity and type 2 diabetes. In this study, we investigated the effects of NNS found in common diet beverages (i.e., sucralose, aspartame, acesulfame potassium) and a natural sweetener (i.e., rebaudioside A) on ER stress in the hypothalamic cell line mHypoE-N43/5 in vivoex vivoShow less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Research team(s) :
Développement et plasticité du cerveau neuro-endocrine
Submission date :
2021-06-23T13:44:35Z