Non-nutritive sweeteners induce hypothalamic ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Non-nutritive sweeteners induce hypothalamic er stress causing abnormal axon outgrowth
Auteur(s) :
Titre de la revue :
Frontiers in Endocrinology
Nom court de la revue :
Front Endocrinol (Lausanne)
Numéro :
10
Pagination :
876
Date de publication :
2019-01-01
ISSN :
1664-2392
Mot(s)-clé(s) :
hypothalamus
aspartame
acesulfame potassium
sucralose
rebaudioside A
ER stress
development
plasticity
aspartame
acesulfame potassium
sucralose
rebaudioside A
ER stress
development
plasticity
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
With the prevalence of obesity, non-nutritive sweeteners (NNS) have been widely used as sugar substitutes as they deliver a sweet taste without excessive caloric load. However, it is increasingly recognized that NNS are ...
Lire la suite >With the prevalence of obesity, non-nutritive sweeteners (NNS) have been widely used as sugar substitutes as they deliver a sweet taste without excessive caloric load. However, it is increasingly recognized that NNS are not inert compounds and may cause long-term metabolic perturbations. Endoplasmic reticulum (ER) stress has emerged as a critical link in the development of obesity and type 2 diabetes. In this study, we investigated the effects of NNS found in common diet beverages (i.e., sucralose, aspartame, acesulfame potassium) and a natural sweetener (i.e., rebaudioside A) on ER stress in the hypothalamic cell line mHypoE-N43/5 in vivoex vivoLire moins >
Lire la suite >With the prevalence of obesity, non-nutritive sweeteners (NNS) have been widely used as sugar substitutes as they deliver a sweet taste without excessive caloric load. However, it is increasingly recognized that NNS are not inert compounds and may cause long-term metabolic perturbations. Endoplasmic reticulum (ER) stress has emerged as a critical link in the development of obesity and type 2 diabetes. In this study, we investigated the effects of NNS found in common diet beverages (i.e., sucralose, aspartame, acesulfame potassium) and a natural sweetener (i.e., rebaudioside A) on ER stress in the hypothalamic cell line mHypoE-N43/5 in vivoex vivoLire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Équipe(s) de recherche :
Développement et plasticité du cerveau neuro-endocrine
Date de dépôt :
2021-06-23T13:44:35Z