Titre :

Non-nutritive sweeteners induce hypothalamic er stress causing abnormal axon outgrowth

Auteur(s) :

Park, Soyoung [Auteur]
Sethi, Sunjay [Auteur]
Bouret, Sebastien [Auteur]

Titre de la revue :

Frontiers in Endocrinology

Nom court de la revue :

Front Endocrinol (Lausanne)

Numéro :

10

Pagination :

876

Date de publication :

2019-01-01

ISSN :

1664-2392

Mot(s)-clé(s) :

hypothalamus
aspartame
acesulfame potassium
sucralose
rebaudioside A
ER stress
development
plasticity

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

With the prevalence of obesity, non-nutritive sweeteners (NNS) have been widely used as sugar substitutes as they deliver a sweet taste without excessive caloric load. However, it is increasingly recognized that NNS are ...
Lire la suite >With the prevalence of obesity, non-nutritive sweeteners (NNS) have been widely used as sugar substitutes as they deliver a sweet taste without excessive caloric load. However, it is increasingly recognized that NNS are not inert compounds and may cause long-term metabolic perturbations. Endoplasmic reticulum (ER) stress has emerged as a critical link in the development of obesity and type 2 diabetes. In this study, we investigated the effects of NNS found in common diet beverages (i.e., sucralose, aspartame, acesulfame potassium) and a natural sweetener (i.e., rebaudioside A) on ER stress in the hypothalamic cell line mHypoE-N43/5 in vivoex vivoLire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Développement et plasticité du cerveau neuro-endocrine

Date de dépôt :

2021-06-23T13:44:35Z