Frequency and characteristics of short ...
Document type :
Article dans une revue scientifique: Article original
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Title :
Frequency and characteristics of short versus longitudinally extensive myelitis in adults with mog antibodies: a retrospective multicentric study
Author(s) :
Ciron, Jonathan [Auteur]
Cobo-Calvo, Alvaro [Auteur]
Audoin, Bertrand [Auteur]
Bourre, Bertrand [Auteur]
Brassat, David [Auteur]
Cohen, Mikael [Auteur]
Collongues, Nicolas [Auteur]
Deschamps, Romain [Auteur]
Durand-Dubief, Francoise [Auteur]
Laplaud, David [Auteur]
Maillart, Elisabeth [Auteur]
Papeix, Caroline [Auteur]
ZEPHIR, Helene [Auteur]
Bereau, Matthieu [Auteur]
Brochet, Bruno [Auteur]
Carra-Dalliere, Clarisse [Auteur]
Derache, Nathalie [Auteur]
Gagou-Scherer, Clarisse [Auteur]
Henry, Carole [Auteur]
Kerschen, Philippe [Auteur]
Mathey, Guillaume [Auteur]
Maubeuge, Nicolas [Auteur]
Maurousset, Aude [Auteur]
Montcuquet, Alexis [Auteur]
Moreau, Thibault [Auteur]
Prat, Christophe [Auteur]
Taithe, Frederic [Auteur]
Thouvenot, Eric [Auteur]
Tourbah, Ayman [Auteur]
Rollot, Fabien [Auteur]
Vukusic, Sandra [Auteur]
Marignier, Romain [Auteur]
Cobo-Calvo, Alvaro [Auteur]
Audoin, Bertrand [Auteur]
Bourre, Bertrand [Auteur]
Brassat, David [Auteur]
Cohen, Mikael [Auteur]
Collongues, Nicolas [Auteur]
Deschamps, Romain [Auteur]
Durand-Dubief, Francoise [Auteur]
Laplaud, David [Auteur]
Maillart, Elisabeth [Auteur]
Papeix, Caroline [Auteur]
ZEPHIR, Helene [Auteur]
Bereau, Matthieu [Auteur]
Brochet, Bruno [Auteur]
Carra-Dalliere, Clarisse [Auteur]
Derache, Nathalie [Auteur]
Gagou-Scherer, Clarisse [Auteur]
Henry, Carole [Auteur]
Kerschen, Philippe [Auteur]
Mathey, Guillaume [Auteur]
Maubeuge, Nicolas [Auteur]
Maurousset, Aude [Auteur]
Montcuquet, Alexis [Auteur]
Moreau, Thibault [Auteur]
Prat, Christophe [Auteur]
Taithe, Frederic [Auteur]
Thouvenot, Eric [Auteur]
Tourbah, Ayman [Auteur]
Rollot, Fabien [Auteur]
Vukusic, Sandra [Auteur]
Marignier, Romain [Auteur]
Journal title :
Multiple sclerosis (Houndmills, Basingstoke, England)
Abbreviated title :
Mult. Scler.
Pages :
1352458519849511
Publication date :
2019-05-31
ISSN :
1477-0970
Keyword(s) :
prognosis
Myelin oligodendrocyte glycoprotein
myelitis
Myelin oligodendrocyte glycoprotein
myelitis
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
We aim to (1) determine the frequency and distinctive features of short myelitis (SM) and longitudinally extensive transverse myelitis (LETM) in a cohort of adults with myelin oligodendrocyte glycoprotein (MOG)-antibody ...
Show more >We aim to (1) determine the frequency and distinctive features of short myelitis (SM) and longitudinally extensive transverse myelitis (LETM) in a cohort of adults with myelin oligodendrocyte glycoprotein (MOG)-antibody (Ab)-associated myelitis and (2) determine baseline prognostic factors among MOG-Ab-positive patients whose disease started with myelitis. We retrospectively analyzed clinical and paraclinical variables from a multicentric French cohort of adults with MOG-Ab-associated myelitis. At last follow-up, patients were classified into two groups according to the severity of the Expanded Disability Status Scale (EDSS) as ⩽2.5 or ⩾3.0. Seventy-three patients with at least one episode of myelitis over disease course were included; among them, 28 (38.4%) presented with SM at the time of the first myelitis. Motor and sphincter involvement was less frequently observed in SM (51.9% and 48.2%, respectively) than in LETM patients (83.3% and 78.6%, respectively), pppppp SM in MOG-Ab-associated disease is not rare. The severity at onset was the only independent factor related to the final prognosis in MOG-Ab-associated myelitis.Show less >
Show more >We aim to (1) determine the frequency and distinctive features of short myelitis (SM) and longitudinally extensive transverse myelitis (LETM) in a cohort of adults with myelin oligodendrocyte glycoprotein (MOG)-antibody (Ab)-associated myelitis and (2) determine baseline prognostic factors among MOG-Ab-positive patients whose disease started with myelitis. We retrospectively analyzed clinical and paraclinical variables from a multicentric French cohort of adults with MOG-Ab-associated myelitis. At last follow-up, patients were classified into two groups according to the severity of the Expanded Disability Status Scale (EDSS) as ⩽2.5 or ⩾3.0. Seventy-three patients with at least one episode of myelitis over disease course were included; among them, 28 (38.4%) presented with SM at the time of the first myelitis. Motor and sphincter involvement was less frequently observed in SM (51.9% and 48.2%, respectively) than in LETM patients (83.3% and 78.6%, respectively), pppppp SM in MOG-Ab-associated disease is not rare. The severity at onset was the only independent factor related to the final prognosis in MOG-Ab-associated myelitis.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Research team(s) :
Neuroinflammation & Multiple Sclerosis (NEMESIS)
Submission date :
2021-06-23T13:47:08Z