Titre :

Tubulointerstitial damage and interstitial immune cell phenotypes are useful predictors for renal survival and relapse in antineutrophil cytoplasmic antibody-associated vasculitis

Auteur(s) :

Bitton, Laura [Auteur]
Vandenbussche, Cyrille [Auteur]
Wayolle, Nicolas [Auteur]
Université de Lille
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Gibier, Jean-Baptiste [Auteur]
Service de pathologie [CHU Lille]
Université de Lille
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Cordonnier, Carole [Auteur]
Verine, Jerome [Auteur]
Humez, Sarah [Auteur]
Bataille, Pierre [Auteur]
Lenain, Remi [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Ramdane, Nassima [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Université de Lille
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Azar, Raymond [Auteur]
Mac Namara, Evelyne [Auteur]
Hatron, Pierre-Yves [Auteur]
Service de médecine interne [Lille]
Université de Lille
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Maurage, Claude-Alain [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Perrais, Michael [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Frimat, Marie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Vanhille, Philippe [Auteur]
Glowacki, Francois [Auteur]
Université de Lille
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Buob, David [Auteur]
Copin, Marie-Christine [Auteur]
Mécanismes de la Tumorigénèse et Thérapies Ciblées (M3T) - UMR 8161
Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 [M3T]
Quemeneur, Thomas [Auteur]
Gnemmi, Viviane [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]

Titre de la revue :

Journal of Nephrology

Nom court de la revue :

J. Nephrol.

Pagination :

771–781

Date de publication :

2020-01-08

ISSN :

1724-6059

Mot(s)-clé(s) :

Fibrosis
Macrophage
Interstitial lymphocytic organization
ANCA-associated vasculitis
Th17
Renal relapse

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The aims of this study were to determine whether tubulointerstitial damage in the form of interstitial fibrosis/tubular atrophy and total interstitial inflammation predicted progression to end stage renal disease (ESRD) ...
Lire la suite >The aims of this study were to determine whether tubulointerstitial damage in the form of interstitial fibrosis/tubular atrophy and total interstitial inflammation predicted progression to end stage renal disease (ESRD) and/or renal relapse (RR) in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). One hundred thirteen patients with AAV from six French centers with an index biopsy performed between 2003 and 2013 were included. Histological assessments using the AAV glomerular classification and the kidney allograft Banff classification were performed on pathological review. Biopsy tissues were also investigated by CD3, CD20, CD68, CD163, FOXP3 and RORγt immunohistochemical staining. Competing risks models were calculated. Of the 113 patients, 26 (23.0%) died during follow-up and 29 (25.6%) developed ESRD. Among the 94 patients who achieved remission by the end of induction therapy without developing ESRD, 26 (27.6%) experienced RR. The two independent prognostic factors for ESRD were the estimated glomerular filtration rate at presentation (HR 0.35; 95% CI 0.23–0.51; P < 0.0001) and IF/TA > 25% (HR 2.27; 95% CI 1.18–4.37; P = 0.014). When the distribution of interstitial immune cell phenotypes was included in a second multivariable model, the organization of lymphocytic infiltrates was also an independent predictor of ESRD (HR 2.86; 95% CI 1.35–6.1, P = 0.006). The independent risk factors for RR were a higher CD3/CD20 ratio (HR 1.39; 95% CI 1.05–1.85; P = 0.02) and the presence of RORγt positive cells (HR 2.70; 95% CI 1.11–6.54; P = 0.02). Our results highlight the prognostic value of initial histological evaluations in AAV. Measurements of tubulointerstitial damage and interstitial immune cell phenotype distributions should be considered to improve risk assessments for ESRD and RR.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Institut Pasteur de Lille
Université de Lille

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
• Lille Neurosciences & Cognition (LilNCog) - U 1172
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
• Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290

Équipe(s) de recherche :

Développement et plasticité du cerveau neuro-endocrine

Date de dépôt :

2021-06-23T13:47:25Z
2025-03-05T14:13:16Z