Title :

Glycosphingolipids and neuroinflammation in parkinson''s disease

Author(s) :

Belarbi, Karim-Ali [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Cuvelier, Elodie [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Bonte, Marie-Amandine [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
CIC CHU ( Lille)/inserm
Lille Neurosciences & Cognition (LilNCog) - U 1172
Desplanque, Mazarine [Auteur]
CIC CHU ( Lille)/inserm
Gressier, Bernard [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
DEVOS, DAVID [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Chartier Harlin, Marie-Christine [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172

Journal title :

Molecular neurodegeneration

Abbreviated title :

Mol Neurodegener

Volume number :

15

Pages :

59

Publisher :

BMC

Publication date :

2020-10-17

ISSN :

1750-1326

Keyword(s) :

Neurodegenerative Diseases
Parkinson Disease
Sphingolipids
Gaucher Disease
Gangliosides
Synucleinopathies
Glucocerebrosides
Glucosylceramides
Lipids
Microglia

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Parkinson's disease is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons of the nigrostriatal pathway and the formation of neuronal inclusions known as Lewy bodies. Chronic ...
Show more >Parkinson's disease is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons of the nigrostriatal pathway and the formation of neuronal inclusions known as Lewy bodies. Chronic neuroinflammation, another hallmark of the disease, is thought to play an important role in the neurodegenerative process. Glycosphingolipids are a well-defined subclass of lipids that regulate crucial aspects of the brain function and recently emerged as potent regulators of the inflammatory process. Deregulation in glycosphingolipid metabolism has been reported in Parkinson’s disease. However, the interrelationship between glycosphingolipids and neuroinflammation in Parkinson’s disease is not well known. This review provides a thorough overview of the links between glycosphingolipid metabolism and immune-mediated mechanisms involved in neuroinflammation in Parkinson’s disease. After a brief presentation of the metabolism and function of glycosphingolipids in the brain, it summarizes the evidences supporting that glycosphingolipids (i.e. glucosylceramides or specific gangliosides) are deregulated in Parkinson’s disease. Then, the implications of these deregulations for neuroinflammation, based on data from human inherited lysosomal glycosphingolipid storage disorders and gene-engineered animal studies are outlined. Finally, the key molecular mechanisms by which glycosphingolipids could control neuroinflammation in Parkinson’s disease are highlighted. These include inflammasome activation and secretion of pro-inflammatory cytokines, altered calcium homeostasis, changes in the blood-brain barrier permeability, recruitment of peripheral immune cells or production of autoantibodies.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires
Brain Biology & Chemistry (BBC)

Submission date :

2021-06-23T13:48:20Z
2022-01-19T09:51:21Z