Titre :

Severe toxoplasmosis imported from tropical Africa in immunocompetent patients: A case series

Auteur(s) :

Leroy, Jordan [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Houzé, Sandrine [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Dardé, Marie-Laure [Auteur]
Centre National de Référence (CNR) Toxoplasmose/Toxoplasma Biological Resource Center (BRC) [CNR Toxoplasmose-Toxoplasma BRC]
Neuroépidémiologie Tropicale [NET]
Yéra, Hélène [Auteur]
Hôpital Cochin [AP-HP]
Rossi, Benjamin [Auteur]
Hôpital Beaujon [AP-HP]
Delhaes, Laurence [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Gabriel, Frédéric [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Loubet, Paul [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Deleplancque, Anne-Sophie [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Senneville, Eric [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Centre Hospitalier Gustave Dron [Tourcoing]
Ajana, Faïza [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Sendid, Boualem [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Lille Inflammation Research International Center (LIRIC) - U995
Malvy, Denis [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]

Titre de la revue :

TRAVEL MEDICINE AND INFECTIOUS DISEASE

Nom court de la revue :

Travel Medicine and Infectious Disease

Pagination :

101509

Éditeur :

Elsevier BV

Date de publication :

2020-05

ISSN :

1477-8939

Mot(s)-clé(s) en anglais :

Toxoplasmosis
Toxoplasma gondii
Tropical Africa
Genotype
Imported cases
Immunocompetent

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Toxoplasmosis is a zoonosis caused by the protozoan Toxoplasma gondii. In immunocompetent patients the infection is usually benign. However, cases of severe and even lethal primo-infections are regularly ...
Lire la suite >Background Toxoplasmosis is a zoonosis caused by the protozoan Toxoplasma gondii. In immunocompetent patients the infection is usually benign. However, cases of severe and even lethal primo-infections are regularly reported in South America. In contrast, data from tropical Africa are fragmentary. Methods Data for French cases of severe toxoplasmosis acquired between 2013 and 2018, in tropical Africa and among immunocompetent patients were collected retrospectively in 2018. Results Four male patients with a mean age of 34-years were identified. All infections originated in West or Central Africa. The clinical presentations were heterogeneous: two patients had severe disseminated toxoplasmosis, of which one presented with chorioretinitis associated with myositis and the other with febrile pneumopathy; one patient presented with post-infectious acute cerebellar ataxia and the final case had general symptoms and skin manifestations. The diagnosis of acute toxoplasmosis was confirmed by serology in four patients. Molecular diagnosis confirmed T. gondii infection in three patients with Africa 1 as the dominant genotype. The infection was cured with anti-infective treatment in all four patients. Ocular sequelae were reported in the two patients with chorioretinitis. Conclusions Imported cases of severe toxoplasmosis in immunocompetent patients are rare in France. However, this aetiology should be evoked rapidly in a patient with a severe infectious syndrome who has recently visited or originated from tropical Africa.Lire moins >

Langue :

Anglais

Audience :

Non spécifiée

Établissement(s) :

Université de Lille
CNRS

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Équipe(s) de recherche :

Glycobiology in fungal Pathogenesis and Clinical Applications

Date de dépôt :

2021-07-05T09:21:46Z
2021-07-07T09:01:58Z