Title :

Tetrahydrocurcumin encapsulation in cyclodextrins for water solubility improvement: synthesis, characterization and antifungal activity as a new biofungicide

Author(s) :

Loron, Anne [Auteur]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Gardrat, Christian [Auteur]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Martel, Bernard [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Coma, Véronique [Auteur]
Laboratoire de Chimie des Polymères Organiques [LCPO]

Journal title :

Carbohydrate Polymer Technologies and Applications

Pages :

100113

Publisher :

Elsevier BV

Publication date :

2021-07-03

Article status :

À paraître

ISSN :

2666-8939

English keyword(s) :

Cyclodextrins tetrahydrocurcumin encapsulation
methylated β-cyclodextrin
F. graminearum
antifungal activity

HAL domain(s) :

Chimie/Matériaux
Chimie/Polymères

English abstract : [en]

The solubility of the scarcely water-soluble molecule tetrahydrocurcumin (THC), a promising curcumin derivative to be used as biopesticide, was enhanced through the formation of inclusion complexes with different cyclodextrins ...
Show more >The solubility of the scarcely water-soluble molecule tetrahydrocurcumin (THC), a promising curcumin derivative to be used as biopesticide, was enhanced through the formation of inclusion complexes with different cyclodextrins (CDs). Randomly methylated β-cyclodextrin (MeβCD) gave the best results among the different CDs whose size, substituent or structure was changing. Differential scanning calorimetry as well as 1H- and 2D-Nuclear Magnetic Resonance (NMR) proved the inclusion of THC in MeβCD. Rotating-frame Overhauser effect spectroscopy NMR especially illustrated specific interactions of aromatic protons of THC and protons located inside the CD cavity. The complex formation between THC and MeβCD was studied using the Higuchi and Connor method, giving an association constant of 591 M−1. THC-loaded MeβCD did not show any growth inhibition of the target fungus Fusarium graminearum. However, THC-loaded MeβCD polymers exhibited 25 % inhibition of the fungal growth, thus making them promising material for solvent-free, aqueous and bio-based fungicide formulations.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Ingénierie des Systèmes Polymères

Submission date :

2021-07-05T12:06:15Z
2021-07-06T13:14:26Z