Title :

Risk factors of early mortality and morbidity in esophageal atresia with distal tracheo-esophageal fistula: a population-based cohort study

Author(s) :

Sfeir, Rony [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Rousseau, Veronique [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Bonnard, Arnaud [Auteur]
Hôpital Robert Debré
Gelas, Thomas [Auteur]
Hospices Civils de Lyon [HCL]
Aumar, Madeleine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Panait, Nicoleta [Auteur]
CHU Marseille
Piolat, C. [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Irtan, Sabine [Auteur]
CHU Trousseau [APHP]
Fouquet, Virginie [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Le Mandat, Aurélie [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
De Napoli, S. [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Habonimana, E. [Auteur]
Centre Hospitalier Universitaire [Rennes]
Lamireau, T. [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Lemelle, J. L. [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
El Baz, Frederic [Auteur]
CHU Rouen
Talon, Isabelle [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Polimerol, M. L. [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Allal, H. [Auteur]
CHU Montpellier = Montpellier University Hospital
Buisson, Ph [Auteur]
CHU Amiens-Picardie
Petit, T. [Auteur]
CHU Caen
Louis, D. [Auteur]
Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand [CHU Dijon]
Lardy, H. [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Schmitt, F. [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Levard, G. [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Scalabre, A. [Auteur]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Michel, J. L. [Auteur]
Centre Hospitalier Universitaire de La Réunion [CHU La Réunion]
Jaby, O. [Auteur]
CHI Créteil
Pelatan, Cécile [Auteur]
Centre Hospitalier Le Mans (CH Le Mans)
De Vries, Philine [Auteur]
Centre Hospitalier Régional Universitaire de Brest [CHRU Brest]
Borderon, Corinne [Auteur]
CHU Clermont-Ferrand
Fourcade, L. [Auteur]
Service de Pédiatrie médicale [CHU Limoges]
Breaud, J. [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Pouzac, M. [Auteur]
Centre Hospitalier Régional d'Orléans [CHRO]
Tolg, C. [Auteur]
Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] [CHU de Martinique]
Chaussy, Y. [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Jochault-Ritz, S. [Auteur]
CH Colmar
Laplace, C. [Auteur]
CHU Pointe-à-Pitre / Abymes [Guadeloupe]
Drumez, Elodie [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Gottrand, fréderic [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]

Journal title :

The Journal of Pediatrics

Abbreviated title :

J Pediatr

Publication date :

2021-03-02

ISSN :

1097-6833

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: To identify the risk factors for early mortality and morbidity in a population with distal esophageal atresia (EA)-tracheoesophageal fistula. METHODS: Cohort study from a national register. Main outcomes and ...
Show more >OBJECTIVE: To identify the risk factors for early mortality and morbidity in a population with distal esophageal atresia (EA)-tracheoesophageal fistula. METHODS: Cohort study from a national register. Main outcomes and measures included early mortality, hospital length of stay (LoS), need for nutritional support at 1 year of age as a proxy measure of morbidity, and complications during the first year of life. RESULTS: In total, 1008 patients with a lower esophageal fistula were included from January 1, 2008, to December 31, 2014. The survival rate at 3 months was 94.9%. The cumulative hospital LoS was 31.0 (17.0-64.0) days. Multivariate analysis showed that intrahospital mortality at 3 months was associated with low birth weight (OR 0.52, 95% CI [0.38-0.72], P < .001), associated cardiac abnormalities (OR 6.09 [1.96-18.89], P = .002), and prenatal diagnosis (OR 2.96 [1.08-8.08], P = .034). LoS was associated with low birth weight (-0.225 ± 0.035, P < .001), associated malformations (0.082 ± 0.118, P < .001), surgical difficulties (0.270 ± 0.107, P < .001), and complications (0.535 ± 0.099, P < .001) during the first year of life. Predictive factors for dependency on nutrition support at 1 year of age were complications before 1 year (OR 3.28 [1.23-8.76], P < .02) and initial hospital LoS (OR 1.96 [1.15-3.33], P < .01). CONCLUSIONS: EA has a low rate of early mortality, but morbidity is high during the first year of life. Identifying factors associated with morbidity may help to improve neonatal care of this population.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2021-07-06T12:44:38Z
2024-03-05T13:58:30Z