Title :

Impact of aging on phenotype and prognosis in iga vasculitis

Author(s) :

Audemard-Verger, Alexandra [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Université de Tours [UT]
Pillebout, Evangeline [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Baldolli, Aurelie [Auteur]
Unité de Maladies Infectieuses et Tropicales [CHU Caen]
Le Gouellec, Noémie [Auteur]
Centre hospitalier [Valenciennes, Nord]
Augusto, Jean-Francois [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Jourde-Chiche, Noémie [Auteur]
Aix Marseille Université [AMU]
Assistance Publique - Hôpitaux de Marseille [APHM]
Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research [C2VN]
Raffray, Loic [Auteur]
Centre Hospitalier Universitaire de La Réunion [CHU La Réunion]
Processus Infectieux en Milieu Insulaire Tropical [PIMIT]
Thervet, Eric [Auteur]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Deroux, Alban [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Goutte, Julie [Auteur]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Hummel, Aurelie [Auteur]
Département de Néphrologie [CHU Necker]
Lioger, Bertrand [Auteur]
Centre Hospitalier de Blois [CHB]
Sanges, Sébastien [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Cacoub, Patrice [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] [I3]
Amoura, Zahir [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Moulis, Guillaume [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Centre d'investigation clinique de Toulouse [CIC 1436]
Maurier, Francois [Auteur]
Hôpital-Clinique Claude-Bernard [Metz]
Lavigne, Christian [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Urbanski, Geoffrey [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Chanal, Johan [Auteur]
Site Tarnier (hôpital Cochin) - APHP
Faguer, Stanislas [Auteur]
Département de Néphrologie et Transplantation d'organes [CHU Toulouse]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Deriaz, Sophie [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Feirreira-Maldent, Nicole [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Diot, Elisabeth [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Maillot, Francois [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Université de Tours [UT]
Guillevin, Loic [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Hôpital Cochin [AP-HP]
Terrier, Benjamin [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Centre de référence des maladies auto-immunes systémiques rares d'Île-de-France / National Reference Center for Rare Systemic Autoimmune Diseases
Hôpital Cochin [AP-HP]

Journal title :

Rheumatology

Abbreviated title :

Rheumatology (Oxford)

Publication date :

2021-01-07

ISSN :

1462-0332

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: Immunoglobulin A vasculitis (IgAV) is a small-vessel vasculitis most frequently benign in children while the disease is more severe in adults. We aimed to study the impact of age on presentation and outcome of ...
Show more >OBJECTIVE: Immunoglobulin A vasculitis (IgAV) is a small-vessel vasculitis most frequently benign in children while the disease is more severe in adults. We aimed to study the impact of age on presentation and outcome of adult IgAV. METHODS: We conducted a nationwide retrospective study including 260 IgAV patients. Patients were divided into four quartiles according to the age at IgAV diagnosis: <36; 36≤age < 52; 52≤age < 63 and ≥63 years. Comparison of presentation and outcome were performed according to age of disease onset. RESULTS: Mean age at diagnosis was 50.1 ± 18 years and 63% were male. IgAV diagnosed in the lowest quartile of age was associated with more frequent joint (p< 0.0001) and gastrointestinal involvement (p= 0.001). In contrast, the oldest patients had more severe purpura with necrotic lesions (p= 0.001) and more frequent renal involvement (p< 0.0001), with more frequent hematuria, renal failure, higher urine protein excretion and more frequent tubulointerstitial lesions. Patients were treated similarly in all groups of age, and clinical response and relapse rates were similar between groups. In the 127 treated patients with follow-up data for >6 months, clinical response and relapse rates were similar between the four groups. Median follow-up was of 17.2 months (9.1-38.3 months). Renal failure at the end of follow-up was significantly more frequent in the highest quartile of age (p= 0.02), but the occurrence of end-stage renal disease was similar in all groups. Last, overall and IgAV-related deaths were associated with increase age. CONCLUSIONS: Aging negatively impacts the severity and outcome of IgAV in adults. Younger patients have more frequent joint and gastrointestinal involvement, while old patients display more frequent severe purpura and glomerulonephritis.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:44:51Z
2024-03-05T09:19:37Z