Titre :

Defining and assessing the reproducibility of crohn's disease endoscopic lesions: a delphi-like method from the getaid

Auteur(s) :

Buisson, Anthony [Auteur]
Filippi, J. [Auteur]
Amiot, A. [Auteur]
Cadiot, G. [Auteur]
Allez, M. [Auteur]
Marteau, P. [Auteur]
Bouhnik, Yoram [Auteur]
Pineton De Chambrun, Guillaume [Auteur]
Pelletier, A. L. [Auteur]
Nancey, Stéphane [Auteur]
Moussata, D. [Auteur]
Attar, A. [Auteur]
Blain, A. [Auteur]
Vuitton, L. [Auteur]
Vernier-Massouille, G. [Auteur]
Seksik, P. [Auteur]
Nachury, Maria [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Dupas, J. L. [Auteur]
Laharie, David [Auteur]
Peyrin-Biroulet, Laurent [Auteur]
Louis, E. [Auteur]
Mary, J. Y. [Auteur]

Titre de la revue :

Journal of Crohn's & colitis

Nom court de la revue :

J Crohns Colitis

Date de publication :

2020-12-12

ISSN :

1876-4479

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

OBJECTIVE: Defining and assessing the reproducibility of Crohn's disease [CD] endoscopic lesions is essential in assessing endoscopic healing. METHODS: Twelve endoscopic CD experts from the GETAID defined aphthoid erosions ...
Lire la suite >OBJECTIVE: Defining and assessing the reproducibility of Crohn's disease [CD] endoscopic lesions is essential in assessing endoscopic healing. METHODS: Twelve endoscopic CD experts from the GETAID defined aphthoid erosions [AE], superficial ulcerations [SU], deep ulcerations [DU], stenosis, and fistulas according to a Delphi-like method. Thirty different GETAID physicians declared if they found acceptable each definition. Intra- and inter-observer agreements were investigated using 100 videos with one tagged specific lesion [AE, SU, DU, or sham lesion] read by 15 independent endoscopists at baseline and 1 month later in a randomised order. Video quality was determined by an external reader. According to kappa estimate [κ ±standard error], intra or inter-observer agreement was qualified as 'moderate' [0.4-0.6], 'substantial' [0.6-0.8], or 'almost perfect' [0.8-1.0]. RESULTS: Among 30 different experts, 83% to 97% found acceptable the definitions retrieved from the Delphi-like method. Intra-observer κ was 0.717 [±0.019] for SU, 0.681 [±0.027] for AE, 0.856 [±0.014] for DU, showing 'substantial' agreement. It was 0.801 [±0.016] for any ulceration [DU or SU]. There was a high variability across readers from 'moderate' to 'almost perfect' agreement. Inter-observer κ was 0.548 [±0.042] for SU, 0.554 [±0.028] for AE 0.694 [±0.041] for DU, and 0.705 [±0.042] for any ulceration. Inter-observer agreement increased when reading the 53 high-quality videos: 0.787 [±0.064] [p = 0.001], 0.607 [±0.043] [p = 0.001], and 0.782 [±0.064][p = 0.001] for DU, AE, and any ulceration, respectively. CONCLUSIONS: Despite variable intra-agreement level across readers, the GETAID definitions for CD endoscopic lesions provided 'substantial' inter-observer agreements, especially in case of high-quality videos.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2021-07-06T12:44:56Z