Early trajectories of skin thickening are ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis
Auteur(s) :
Ledoult, Emmanuel [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Launay, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Behal, Helene [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Mouthon, Luc [Auteur]
Pugnet, Gregory [Auteur]
Lega, Jean-Christophe [Auteur]
Agard, Christian [Auteur]
Allanore, Yannick [Auteur]
Jego, Patrick [Auteur]
Fauchais, Anne-Laure [Auteur]
Harle, Jean-Robert [Auteur]
Berthier, Sabine [Auteur]
Aouba, Achille [Auteur]
Mekinian, Arsene [Auteur]
Diot, Elisabeth [Auteur]
Truchetet, Marie-Elise [Auteur]
Boulon, Carine [Auteur]
Duhamel, Alain [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Sobanski, Vincent [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Launay, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Behal, Helene [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Mouthon, Luc [Auteur]
Pugnet, Gregory [Auteur]
Lega, Jean-Christophe [Auteur]
Agard, Christian [Auteur]
Allanore, Yannick [Auteur]
Jego, Patrick [Auteur]
Fauchais, Anne-Laure [Auteur]
Harle, Jean-Robert [Auteur]
Berthier, Sabine [Auteur]
Aouba, Achille [Auteur]
Mekinian, Arsene [Auteur]
Diot, Elisabeth [Auteur]
Truchetet, Marie-Elise [Auteur]
Boulon, Carine [Auteur]
Duhamel, Alain [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Sobanski, Vincent [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Titre de la revue :
Arthritis Research & Therapy
Nom court de la revue :
Arthritis Res. Ther.
Numéro :
22
Pagination :
30
Date de publication :
2020-02-18
ISSN :
1478-6362
Mot(s)-clé(s) :
Skin thickening trajectories
Clinical heterogeneity
Systemic sclerosis
Modified Rodnan skin score
Clinical heterogeneity
Systemic sclerosis
Modified Rodnan skin score
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Systemic sclerosis (SSc) is a severe and highly heterogeneous disease. The modified Rodnan skin score (mRSS) is a widely used tool for the assessment of the extent and degree of skin thickness. This study aimed to identify ...
Lire la suite >Systemic sclerosis (SSc) is a severe and highly heterogeneous disease. The modified Rodnan skin score (mRSS) is a widely used tool for the assessment of the extent and degree of skin thickness. This study aimed to identify the classes of patients with early similar skin thickening trajectories without any a priori assumptions and study their associations with organ involvement and survival. From the French SSc national cohort, patients with a disease duration of less than 2 years at inclusion and with at least 2 mRSS available within the first 4 years of follow-up were enrolled. Classes of patients with similar mRSS trajectories were identified based on a latent class mixed model. The clinical characteristics and survival rate were compared between the obtained classes. A total of 198 patients fulfilled the inclusion criteria, with a total of 641 mRSS available. The median disease duration and follow-up were 0.8 (interquartile range 0.4; 1.2) and 6.3 (3.8; 8.9) years, respectively. Individual trajectories of mRSS were highly heterogeneous between patients. Models with 1-6 latent classes of trajectories were sequentially assessed, and the 5-class model represented the best fit to data. Each class was characterized by a unique global trajectory of mRSS. The median disease duration did not differ significantly between classes. Baseline organ involvement was more frequent in classes with significant change over time (classes 2-5) than in class 1 (low baseline mRSS without significant change over time). Using Cox regression, we observed a progressively increasing risk of death from classes 1 to 5. Early identification of clinical phenotype based on skin thickening trajectories could predict morbi-mortality in SSc. This study suggested that mRSS trajectories characterization might be pivotal for clinical practice and future trial designs.Lire moins >
Lire la suite >Systemic sclerosis (SSc) is a severe and highly heterogeneous disease. The modified Rodnan skin score (mRSS) is a widely used tool for the assessment of the extent and degree of skin thickness. This study aimed to identify the classes of patients with early similar skin thickening trajectories without any a priori assumptions and study their associations with organ involvement and survival. From the French SSc national cohort, patients with a disease duration of less than 2 years at inclusion and with at least 2 mRSS available within the first 4 years of follow-up were enrolled. Classes of patients with similar mRSS trajectories were identified based on a latent class mixed model. The clinical characteristics and survival rate were compared between the obtained classes. A total of 198 patients fulfilled the inclusion criteria, with a total of 641 mRSS available. The median disease duration and follow-up were 0.8 (interquartile range 0.4; 1.2) and 6.3 (3.8; 8.9) years, respectively. Individual trajectories of mRSS were highly heterogeneous between patients. Models with 1-6 latent classes of trajectories were sequentially assessed, and the 5-class model represented the best fit to data. Each class was characterized by a unique global trajectory of mRSS. The median disease duration did not differ significantly between classes. Baseline organ involvement was more frequent in classes with significant change over time (classes 2-5) than in class 1 (low baseline mRSS without significant change over time). Using Cox regression, we observed a progressively increasing risk of death from classes 1 to 5. Early identification of clinical phenotype based on skin thickening trajectories could predict morbi-mortality in SSc. This study suggested that mRSS trajectories characterization might be pivotal for clinical practice and future trial designs.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Date de dépôt :
2021-07-06T12:46:48Z
2024-01-09T13:29:52Z
2024-01-09T13:32:46Z
2024-01-09T13:29:52Z
2024-01-09T13:32:46Z
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