Title :

Severe preschool asthmatics have altered cytokine and anti-viral responses during exacerbation

Author(s) :

Lejeune, Stephanie [Auteur]
Pichavant, Muriel [Auteur]
Engelmann, Ilka [Auteur]
Pathogenèse virale du diabète de type 1 - ULR 3610
Beghin, Laurent [Auteur]
Drumez, Elodie [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Le Rouzic, Olivier [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Dessein, Rodrigue [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Rogeau, Stephanie [Auteur]
Beke, Timothee [Auteur]
Kervoaze, Gwenola [Auteur]
Delvart, Celine [Auteur]
Ducoin, Heloise [Auteur]
Pouessel, Guillaume [Auteur]
Le Mee, Armelle [Auteur]
Boileau, Sophie [Auteur]
Roussel, Juliette [Auteur]
Bonnel, Cecile [Auteur]
Mordacq, Clemence [Auteur]
Thumerelle, Caroline [Auteur]
Gosset, Philippe [Auteur]
Deschildre, Antoine [Auteur]

Journal title :

Pediatric allergy and immunology . official publication of the European Society of Pediatric Allergy and Immunology

Abbreviated title :

Pediatr Allergy Immunol

Publication date :

2020-04-30

ISSN :

1399-3038

Keyword(s) :

asthma
infection
inflammation
phenotype
preschool children

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Preschool asthma/recurrent wheeze is a heterogeneous condition. Different clinical phenotypes have been described, including episodic viral wheeze (EVW), severe intermittent wheeze (SIW), and multiple-trigger wheeze (MTW). To ...
Show more >Preschool asthma/recurrent wheeze is a heterogeneous condition. Different clinical phenotypes have been described, including episodic viral wheeze (EVW), severe intermittent wheeze (SIW), and multiple-trigger wheeze (MTW). To compare clinical, viral, and inflammatory/immune profiling at exacerbation between MTW, SIW, and EVW phenotypes. Multicenter, prospective, observational cohort (VIRASTHMA-2). Children (1-5 years) with preschool asthma were enrolled during hospitalization for a severe exacerbation. History and anamnestic data, plasma, and nasal samples were collected at exacerbation (T1) and at steady state, 8 weeks later (T2), and sputum samples were collected at T1. A total of 147 children were enrolled, 37 (25%) had SIW, 18 (12.2%) EVW, and 92 (63%) MTW. They were atopic (47%), exposed to mold (22%) and cigarette smoke (50%), and prone to exacerbations (≥2 in the previous year in 70%). At exacerbation, at least one virus was isolated in 94% and rhinovirus in 75%, with no difference between phenotypes. Children with MTW and SIW phenotypes displayed lower plasma concentrations of IFN-γ (P = .002), IL-5 (P = .020), TNF-α (P = .038), IL-10 (P = .002), IFN-β (P = .036), and CXCL10 (P = .006) and lower levels of IFN-γ (P = .047) in sputum at exacerbation than children with EVW. At T2, they also displayed lower plasma levels of IFN-γ (P = .045) and CXCL10 (P = .013). Among preschool asthmatic children, MTW and SIW, prone to exacerbations, display lower systemic levels of Th1, Th2 cytokines, pro- and anti-inflammatory cytokines, and antiviral responses during severe virus-induced exacerbation.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Institut Pasteur de Lille
Université de Lille

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
• Pathogenèse virale du diabète de type 1 - ULR 3610

Submission date :

2021-07-06T12:47:09Z