Outcome of patients treated with molecular ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Outcome of patients treated with molecular adsorbent recirculating system albumin dialysis: a national multicenter study
Auteur(s) :
Camus, Christophe [Auteur]
Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Locher, Clara [Auteur]
Centre d'Investigation Clinique [Rennes] [CIC]
Saliba, Faouzi [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Goubaux, Bernard [Auteur]
Hôpital l'Archet
Bonadona, Agnes [Auteur]
Hôpital la Tronche
Lavayssiere, Laurence [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Paugam, Catherine [Auteur]
Hôpital Beaujon [AP-HP]
Quinart, Alice [Auteur]
Service Anesthésie - Réanimation [Bordeaux]
Barbot, Olivier [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Dharancy, Sebastien [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Delafosse, Bertrand [Auteur]
Pichon, Nicolas [Auteur]
Service de Réanimation Polyvalente [CHU Limoges]
CHU Limoges
Barraud, Helene [Auteur]
Service d'Hépato-gastro-entérologie [CHRU Nancy]
Galbois, Arnaud [Auteur]
CHU Saint-Antoine [AP-HP]
Veber, Benoit [Auteur]
Hôpital Charles Nicolle [Rouen]
Cayot, Sophie [Auteur]
CHU Estaing [Clermont-Ferrand]
Souche, Bruno [Auteur]
Hôpital Saint Eloi [CHU Montpellier]
Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Locher, Clara [Auteur]
Centre d'Investigation Clinique [Rennes] [CIC]
Saliba, Faouzi [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Goubaux, Bernard [Auteur]
Hôpital l'Archet
Bonadona, Agnes [Auteur]
Hôpital la Tronche
Lavayssiere, Laurence [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Paugam, Catherine [Auteur]
Hôpital Beaujon [AP-HP]
Quinart, Alice [Auteur]
Service Anesthésie - Réanimation [Bordeaux]
Barbot, Olivier [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Dharancy, Sebastien [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Delafosse, Bertrand [Auteur]
Pichon, Nicolas [Auteur]
Service de Réanimation Polyvalente [CHU Limoges]
CHU Limoges
Barraud, Helene [Auteur]
Service d'Hépato-gastro-entérologie [CHRU Nancy]
Galbois, Arnaud [Auteur]
CHU Saint-Antoine [AP-HP]
Veber, Benoit [Auteur]
Hôpital Charles Nicolle [Rouen]
Cayot, Sophie [Auteur]
CHU Estaing [Clermont-Ferrand]
Souche, Bruno [Auteur]
Hôpital Saint Eloi [CHU Montpellier]
Titre de la revue :
Journal of Gastroenterology and Hepatology
Nom court de la revue :
JGH Open
Date de publication :
2020-05-17
ISSN :
2397-9070
Mot(s)-clé(s) :
MARS albumin dialysis
liver transplantation
retrospective study
outcome
liver transplantation
retrospective study
outcome
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
The molecular adsorbent recirculating system (MARS) is the most widely used device to treat liver failure. Nevertheless, data from widespread real-life use are lacking.
This was a retrospective multicenter study conducted ...
Lire la suite >The molecular adsorbent recirculating system (MARS) is the most widely used device to treat liver failure. Nevertheless, data from widespread real-life use are lacking. This was a retrospective multicenter study conducted in all French adult care centers that used MARS between 2004 and 2009. The primary objective was to evaluate patient survival according to the liver disease and listing status. Factors associated with mortality were the secondary objectives. A total of 383 patients underwent 393 MARS treatments. The main indications were acute liver failure (ALF, 32.6%), and severe cholestasis (total bilirubin >340 μmol/L) (37.2%), hepatic encephalopathy (23.7%), and/or acute kidney injury-hepatorenal syndrome (22.9%) most often among patients with chronic liver disease. At the time of treatment, 34.4% of the patients were listed. Overall, the hospital survival rate was 49% (95% CI: 44-54%) and ranged from 25% to 81% depending on the diagnosis of the liver disease. In listed patients versusvsvsvsP Our study suggests that MARS should be mainly used as a bridge to liver transplantation. Survival was correlated with being listed for most etiologies and with the intensity of treatment in ALF.Lire moins >
Lire la suite >The molecular adsorbent recirculating system (MARS) is the most widely used device to treat liver failure. Nevertheless, data from widespread real-life use are lacking. This was a retrospective multicenter study conducted in all French adult care centers that used MARS between 2004 and 2009. The primary objective was to evaluate patient survival according to the liver disease and listing status. Factors associated with mortality were the secondary objectives. A total of 383 patients underwent 393 MARS treatments. The main indications were acute liver failure (ALF, 32.6%), and severe cholestasis (total bilirubin >340 μmol/L) (37.2%), hepatic encephalopathy (23.7%), and/or acute kidney injury-hepatorenal syndrome (22.9%) most often among patients with chronic liver disease. At the time of treatment, 34.4% of the patients were listed. Overall, the hospital survival rate was 49% (95% CI: 44-54%) and ranged from 25% to 81% depending on the diagnosis of the liver disease. In listed patients versusvsvsvsP Our study suggests that MARS should be mainly used as a bridge to liver transplantation. Survival was correlated with being listed for most etiologies and with the intensity of treatment in ALF.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Date de dépôt :
2021-07-06T12:47:10Z
2024-03-28T10:21:30Z
2024-03-28T10:21:30Z
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- JGH Open - 2020 - Camus - Outcome of patients treated with molecular adsorbent recirculating system albumin dialysis A.pdf
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