Title :

Outcome of patients treated with molecular adsorbent recirculating system albumin dialysis: a national multicenter study

Author(s) :

Camus, Christophe [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes]
Locher, Clara [Auteur]
Centre d'Investigation Clinique [Rennes] [CIC]
Saliba, Faouzi [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Goubaux, Bernard [Auteur]
Hôpital l'Archet
Bonadona, Agnes [Auteur]
Hôpital la Tronche
Lavayssiere, Laurence [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Paugam, Catherine [Auteur]
Hôpital Beaujon [AP-HP]
Quinart, Alice [Auteur]
Service Anesthésie - Réanimation [Bordeaux]
Barbot, Olivier [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Dharancy, Sebastien [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Delafosse, Bertrand [Auteur]
Pichon, Nicolas [Auteur]
CHU Limoges
Service de Réanimation Polyvalente [CHU Limoges]
Barraud, Helene [Auteur]
Service d'Hépato-gastro-entérologie [CHRU Nancy]
Galbois, Arnaud [Auteur]
CHU Saint-Antoine [AP-HP]
Veber, Benoit [Auteur]
Hôpital Charles Nicolle [Rouen]
Cayot, Sophie [Auteur]
CHU Estaing [Clermont-Ferrand]
Souche, Bruno [Auteur]
Hôpital Saint Eloi [CHU Montpellier]

Journal title :

Journal of Gastroenterology and Hepatology

Abbreviated title :

JGH Open

Publication date :

2020-05-17

ISSN :

2397-9070

Keyword(s) :

MARS albumin dialysis
liver transplantation
retrospective study
outcome

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The molecular adsorbent recirculating system (MARS) is the most widely used device to treat liver failure. Nevertheless, data from widespread real-life use are lacking. This was a retrospective multicenter study conducted ...
Show more >The molecular adsorbent recirculating system (MARS) is the most widely used device to treat liver failure. Nevertheless, data from widespread real-life use are lacking. This was a retrospective multicenter study conducted in all French adult care centers that used MARS between 2004 and 2009. The primary objective was to evaluate patient survival according to the liver disease and listing status. Factors associated with mortality were the secondary objectives. A total of 383 patients underwent 393 MARS treatments. The main indications were acute liver failure (ALF, 32.6%), and severe cholestasis (total bilirubin >340 μmol/L) (37.2%), hepatic encephalopathy (23.7%), and/or acute kidney injury-hepatorenal syndrome (22.9%) most often among patients with chronic liver disease. At the time of treatment, 34.4% of the patients were listed. Overall, the hospital survival rate was 49% (95% CI: 44-54%) and ranged from 25% to 81% depending on the diagnosis of the liver disease. In listed patients versusvsvsvsP Our study suggests that MARS should be mainly used as a bridge to liver transplantation. Survival was correlated with being listed for most etiologies and with the intensity of treatment in ALF.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:47:10Z
2024-03-28T10:21:30Z