Title :

Hypervitaminosis a is associated with immunological non-response in hiv-1-infected adults: a case-control study

Author(s) :

Melliez, Hugues [Auteur]
Prost, Michel [Auteur]
Laboratoire de Recherche Appliquée Spiral [Bourgogne] [LARA SPIRAL]
Behal, Helene [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Neveux, Nathalie [Auteur]
Benoist, Jean-Francois [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Kim, Isabelle [Auteur]
Mazzella, Sylvie [Auteur]
Derdour, Vincent [Auteur]
Sauser, Evelyne [Auteur]
Robineau, Olivier [Auteur]
Senneville, Eric [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Cynober, Luc [Auteur]
Biekre, Raphael [Auteur]
Seguy, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Journal title :

European Journal of Clinical Microbiology & Infectious Diseases

Abbreviated title :

Eur. J. Clin. Microbiol. Infect. Dis.

Volume number :

39

Pages :

2091–2098

Publication date :

2020-11

ISSN :

1435-4373

Keyword(s) :

Immunological non-response
Antioxidant status
Hypervitaminosis A
HIV
Nutrition

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

For people living with HIV, determinants of immunological non-response (INR) to combined antiretroviral therapy (cART) have not been fully elucidated. In a case-control study, we evaluated the influence of the nutritional ...
Show more >For people living with HIV, determinants of immunological non-response (INR) to combined antiretroviral therapy (cART) have not been fully elucidated. In a case-control study, we evaluated the influence of the nutritional and antioxidant status in HIV-1 adults whose cART was initiated between January 2001 and December 2013. Cases had persistent CD4 counts < 350/μL vs. > 350/μL for controls, after at least 2 years of cART with persistent viral loads (VL) < 50 copies/mL. Twelve cases and twenty-eight control subjects with the same CD4 count at cART initiation were compared for their nutritional and antioxidant status after age adjustment at dosage assessment. Patients were predominantly male (70%), Caucasian (82%) and at AIDS stage (62%). The median age was 53, and the median CD4 count was 245/mm3 for cases and 630/mm3 for controls after a median time of 7 years on cART. Despite higher energy intakes in cases, anthropometric data was comparable between groups who had similar vitamins B9/B12/C/D/E, zinc, citrulline and glutamine levels. Nine cases (75%) and 8 controls (29%) had hypervitaminosis A (> 2.70 μmol/L) (p = 0.030). Cases had lower erythrocyte resistance when exposed to a controlled free radical attack (p = 0.014). Most cases had hypervitaminosis A and altered antioxidant capacities that could affect immunological response. Wide-scale studies are required, but in the meantime, screening of their vitamin A status must be encouraged in these patients.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2021-07-06T12:47:26Z
2024-01-10T09:40:28Z