Title :

Allergooncology: ultra-low ige, a potential novel biomarker in cancer-a position paper of the european academy of allergy and clinical immunology (eaaci)

Author(s) :

Ferastraoaru, D. [Auteur]
Albert Einstein College of Medicine [New York]
Bax, H. J. [Auteur]
King‘s College London
Bergmann, C. [Auteur]
Universitat Duisberg-Essen
Capron, M. [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Castells, M. [Auteur]
Harvard Medical School [Boston] [HMS]
Dombrowicz, D. [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Fiebiger, E. [Auteur]
Boston Children's Hospital
Gould, H. J. [Auteur]
King‘s College London
Hartmann, K. [Auteur]
Jappe, U. [Auteur]
German Center for Lung Research
Jordakieva, G. [Auteur]

Josephs, D. H. [Auteur]
King‘s College London
Levi-Schaffer, F. [Auteur]
The Hebrew University of Jerusalem [HUJ]
Mahler, V. [Auteur]
Paul-Ehrlich-Institute - Federal Institute for Vaccines and Biomedicines [EPI]
Poli, A. [Auteur]
Luxembourg Institute of Health [LIH]
Rosenstreich, D. [Auteur]
Albert Einstein College of Medicine [New York]
Roth-Walter, F. [Auteur]

Shamji, M. [Auteur]
Imperial College London
Steveling-Klein, E. H. [Auteur]
University Hospital Basel [Basel]
Untersmayr, E. [Auteur]

Karagiannis, S. N. [Auteur]
King‘s College London
Jensen-Jarolim, E. [Auteur]

Journal title :

Clinical and Translational Allergy

Abbreviated title :

Clin Transl Allergy

Volume number :

10

Pages :

32

Publication date :

2020-01-01

ISSN :

2045-7022

Keyword(s) :

Cancer
Malignancy
Atopy
Allergy diagnosis
IgE

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated ...
Show more >Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, recent studies reveal a correlation between IgE deficiency and increased malignancy risk. This is the first review discussing IgE levels and links to pathological conditions, with special focus on the potential clinical significance of ultra-low serum IgE levels and risk of malignancy. In this Position Paper we discuss: (a) the utility of measuring total IgE levels in the management of allergies, parasitosis, and immunodeficiencies, (b) factors that may influence serum IgE levels, (c) IgE as a marker of different disorders, and d) the relationship between ultra-low IgE levels and malignancy susceptibility. While elevated serum IgE is generally associated with allergic/atopic conditions, very low or absent IgE may hamper anti-tumour surveillance, indicating the importance of a balanced IgE-mediated immune function. Ultra-low IgE may prove to be an unexpected biomarker for cancer risk. Nevertheless, given the early stage of investigations conducted mostly in patients with diseases that influence IgE levels, in-depth mechanistic studies and stratification of malignancy risk based on associated demographic, immunological and clinical co-factors are warranted.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:47:39Z
2024-01-29T12:45:31Z