Alcoholic hepatitis: towards an era of ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
Permalink :
Title :
Alcoholic hepatitis: towards an era of personalised management
Author(s) :
Degre, Delphine [Auteur]
Ntandja Wandji, Line Carolle [Auteur]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Moreno, Christophe [Auteur]
Université libre de Bruxelles [ULB]
Louvet, Alexandre [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Ntandja Wandji, Line Carolle [Auteur]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Moreno, Christophe [Auteur]
Université libre de Bruxelles [ULB]
Louvet, Alexandre [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Journal title :
United European Gastroenterology Journal
Abbreviated title :
United European Gastroenterol J
Pages :
2050640620945886
Publication date :
2020-07-27
ISSN :
2050-6414
Keyword(s) :
liver transplantation
Alcoholic hepatitis
disease severity
prednisolone
Lille score
Alcoholic hepatitis
disease severity
prednisolone
Lille score
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Alcoholic hepatitis should be suspected in every patient with excessive chronic alcohol consumption and recent onset of jaundice. Diagnosis of alcoholic hepatitis is based on clinical and laboratory findings, and confirmed ...
Show more >Alcoholic hepatitis should be suspected in every patient with excessive chronic alcohol consumption and recent onset of jaundice. Diagnosis of alcoholic hepatitis is based on clinical and laboratory findings, and confirmed by a liver biopsy when available. Several scores are available to assess severity and prognosis of alcoholic hepatitis. The 1-month mortality of patients with severe alcoholic hepatitis, as defined by Maddrey's discriminant function, is 20-30%. Therefore, severe alcoholic hepatitis should be treated with a 28-day course of oral prednisolone after systematic screening for infection. In this review, we discuss diagnosis of alcoholic hepatitis, the different scores to assess severity of the disease, indications for corticosteroid therapy and alternative therapeutic options for non-responders to medical therapy.Show less >
Show more >Alcoholic hepatitis should be suspected in every patient with excessive chronic alcohol consumption and recent onset of jaundice. Diagnosis of alcoholic hepatitis is based on clinical and laboratory findings, and confirmed by a liver biopsy when available. Several scores are available to assess severity and prognosis of alcoholic hepatitis. The 1-month mortality of patients with severe alcoholic hepatitis, as defined by Maddrey's discriminant function, is 20-30%. Therefore, severe alcoholic hepatitis should be treated with a 28-day course of oral prednisolone after systematic screening for infection. In this review, we discuss diagnosis of alcoholic hepatitis, the different scores to assess severity of the disease, indications for corticosteroid therapy and alternative therapeutic options for non-responders to medical therapy.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Submission date :
2021-07-06T12:47:49Z
2024-03-29T10:55:34Z
2024-03-29T10:55:34Z