Alcoholic hepatitis: towards an era of ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Alcoholic hepatitis: towards an era of personalised management
Auteur(s) :
Degre, Delphine [Auteur]
Ntandja Wandji, Line Carolle [Auteur]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Moreno, Christophe [Auteur]
Université libre de Bruxelles [ULB]
Louvet, Alexandre [Auteur]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Ntandja Wandji, Line Carolle [Auteur]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Moreno, Christophe [Auteur]
Université libre de Bruxelles [ULB]
Louvet, Alexandre [Auteur]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Titre de la revue :
United European Gastroenterology Journal
Nom court de la revue :
United European Gastroenterol J
Pagination :
2050640620945886
Date de publication :
2020-07-27
ISSN :
2050-6414
Mot(s)-clé(s) :
liver transplantation
Alcoholic hepatitis
disease severity
prednisolone
Lille score
Alcoholic hepatitis
disease severity
prednisolone
Lille score
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Alcoholic hepatitis should be suspected in every patient with excessive chronic alcohol consumption and recent onset of jaundice. Diagnosis of alcoholic hepatitis is based on clinical and laboratory findings, and confirmed ...
Lire la suite >Alcoholic hepatitis should be suspected in every patient with excessive chronic alcohol consumption and recent onset of jaundice. Diagnosis of alcoholic hepatitis is based on clinical and laboratory findings, and confirmed by a liver biopsy when available. Several scores are available to assess severity and prognosis of alcoholic hepatitis. The 1-month mortality of patients with severe alcoholic hepatitis, as defined by Maddrey's discriminant function, is 20-30%. Therefore, severe alcoholic hepatitis should be treated with a 28-day course of oral prednisolone after systematic screening for infection. In this review, we discuss diagnosis of alcoholic hepatitis, the different scores to assess severity of the disease, indications for corticosteroid therapy and alternative therapeutic options for non-responders to medical therapy.Lire moins >
Lire la suite >Alcoholic hepatitis should be suspected in every patient with excessive chronic alcohol consumption and recent onset of jaundice. Diagnosis of alcoholic hepatitis is based on clinical and laboratory findings, and confirmed by a liver biopsy when available. Several scores are available to assess severity and prognosis of alcoholic hepatitis. The 1-month mortality of patients with severe alcoholic hepatitis, as defined by Maddrey's discriminant function, is 20-30%. Therefore, severe alcoholic hepatitis should be treated with a 28-day course of oral prednisolone after systematic screening for infection. In this review, we discuss diagnosis of alcoholic hepatitis, the different scores to assess severity of the disease, indications for corticosteroid therapy and alternative therapeutic options for non-responders to medical therapy.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Date de dépôt :
2021-07-06T12:47:49Z
2024-03-29T10:55:34Z
2024-03-29T10:55:34Z