Title :

Are autologous stem cell transplants still required to treat myeloma in the era of novel therapies? a review from the chronic malignancies working party of the ebmt

Author(s) :

Garderet, Laurent [Auteur]
Centre de Recherche Saint-Antoine [UMRS893]
Morris, Curly [Auteur]
Queen's University [Belfast] [QUB]
Beksac, Meral [Auteur]
Ankara University School of Medicine [Turkey]
Gahrton, Gösta [Auteur]
Karolinska Institutet [Stockholm]
Schonland, Stefan O. [Auteur]
University of Heidelberg, Medical Faculty
Yakoub-Agha, Ibrahim [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Hayden, Patrick J. [Auteur]
Trinity College Dublin

Journal title :

Biology of blood and marrow transplantation . journal of the American Society for Blood and Marrow Transplantation

Abbreviated title :

Biol. Blood Marrow Transplant.

Publication date :

2020-05-14

ISSN :

1523-6536

Keyword(s) :

Immunotherapy
Myeloma
Autologous stem cell transplantation
CAR T cells

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Melphalan at a myeloablative dose followed by autologous stem cell transplantation (ASCT) remains the standard of care for transplant-eligible patients with myeloma. However, therapies such as new immunomodulatory drugs ...
Show more >Melphalan at a myeloablative dose followed by autologous stem cell transplantation (ASCT) remains the standard of care for transplant-eligible patients with myeloma. However, therapies such as new immunomodulatory drugs and proteasome inhibitors and, more recently, monoclonal antibodies and chimeric antigen receptor T cells are challenging the traditional role of ASCT. Which patients benefit from ASCT? Can its use be delayed until first relapse? The field is moving rapidly as novel agents lead to new patient care strategies. The place of ASCT in this changing landscape will be reviewed and reassessed.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:48:04Z
2024-03-27T10:29:09Z