Title :

Bariatric surgery provides long-term resolution of nonalcoholic steatohepatitis and regression of fibrosis

Author(s) :

Lassailly, Guillaume [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Caiazzo, Robert [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Recherche translationnelle sur le diabète (RTD) - U1190
Ntandja Wandji, Line [Auteur]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Gnemmi, Viviane [Auteur]
Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290
Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Baud, Gregory [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Parent, Helene [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Ningarhari, Massih [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Louvet, Alexandre [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Leteurtre, Emmanuelle [Auteur]
Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290
Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Raverdy, Violetta [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Dharancy, Sebastien [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Pattou, Francois [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Mathurin, Philippe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]

Journal title :

Gastroenterology

Abbreviated title :

Gastroenterology

Publication date :

2020-06-15

ISSN :

1528-0012

Keyword(s) :

Sleeve Gastrectomy
Roux-en-Y-Gastric-Bypass
Gastric Bypass
Gastric Banding

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Studies are needed to determine the long-term effects of bariatric surgery for patients with nonalcoholic steatohepatitis (NASH). We evaluated sequential liver samples, collected the time of bariatric surgery and 1 and 5 ...
Show more >Studies are needed to determine the long-term effects of bariatric surgery for patients with nonalcoholic steatohepatitis (NASH). We evaluated sequential liver samples, collected the time of bariatric surgery and 1 and 5 years later, to assess the long-term effects of bariatric surgery in patients with NASH. We performed a prospective study of 180 severely obese patients with biopsy-proven NASH, defined by the NASH clinical research network histologic scores. The patients underwent bariatric surgery at a single center in France and were followed for 5 years. We obtained liver samples from 125 of 169 patients (76%) having reached 1 year and 64 of 94 patients (68%) having reached 5 years after surgery. The primary endpoint was the resolution of NASH without worsening of fibrosis at 5 years. Secondary end points were improvement in fibrosis (reduction of ≥1 stage) at 5 years and regression of fibrosis and NASH at 1 and 5 years. At 5 years after bariatric surgery, NASH was resolved, without worsening fibrosis, in samples from 84% of patients (n = 64; 95% confidence interval, 73.1%-92.2%). Fibrosis decreased, compared with baseline, in samples from 70.2% of patients (95% CI, 56.6%-81.6%). Fibrosis disappeared from samples from 56% of all patients (95% CI, 42.4%-69.3%) and from samples from 45.5% of patients with baseline bridging fibrosis. Persistence of NASH was associated with no decrease in fibrosis and less weight loss (reduction in body mass index of 6.3 ± 4.1 kg/m22 In a long-term follow-up of patients with NASH who underwent bariatric surgery, we observed resolution of NASH in liver samples from 84% of patients 5 years later. The reduction of fibrosis is progressive, beginning during the first year and continuing through 5 years.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290
• Recherche translationnelle sur le diabète (RTD) - U1190

Submission date :

2021-07-06T12:48:13Z
2024-02-02T10:39:48Z