Title :

Long-term outcome of crohn''s disease patients with upper gastrointestinal stricture: a getaid study

Author(s) :

Lambin, Thomas [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Amiot, Aurelien [Auteur]
Service d'hépato-gastro-entérologie [APHP Henri Mondor]
Stefanescu, Carmen [Auteur]
Hôpital Beaujon
Gornet, Jean-Marc [Auteur]
Hôpital Saint-Louis
Seksik, Philippe [Auteur]
CHU Saint-Antoine [AP-HP]
Laharie, David [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Reenaers, Catherine [Auteur]
Centre Hospitalier Universitaire de Liège [CHU-Liège]
Bourreille, Arnaud [Auteur]
Institut des Maladies de l'Appareil Digestif
Cadiot, Guillaume [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Carbonnel, Franck [Auteur]
Hôpital Bicêtre
Dib, Nina [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Fumery, Mathurin [Auteur]
CHU Amiens-Picardie
Gilletta De St Joseph, Cyrielle [Auteur]
Service de Gastroentérologie et pancréatologie [CHU Toulouse]
Filippi, Jerome [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Viennot, Stéphanie [Auteur]
Service d'Hépato-Gastro-Enterologie et Nutrition [CHU Caen]
Plastaras, Laurianne [Auteur]
Hôpital pasteur [Colmar]
Coffin, Benoit [Auteur]
Hôpital Louis Mourier - AP-HP [Colombes]
Serrero, Melanie [Auteur]
CHU Marseille
Nahon, Stephane [Auteur]
Groupe Hospitalier Intercommunal Le Raincy-Montfermeil
Pineton De Chambrun, Guillaume [Auteur]
Hôpital Saint Eloi [CHU Montpellier]
Rahier, Jean-Francois [Auteur]
CHU UCL Namur
Roblin, Xavier [Auteur]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Boualit, Medina [Auteur]
Centre hospitalier [Valenciennes, Nord]
Bouguen, Guillaume [Auteur]
Centre Hospitalier Universitaire [Rennes]
Peyrin-Biroulet, Laurent [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Pariente, Benjamin [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]

Journal title :

Digestive and Liver Disease

Abbreviated title :

Dig Liver Dis

Publication date :

2020-09-19

ISSN :

1878-3562

Keyword(s) :

Crohn's disease
Endoscopic treatment
Surgery
Stricture
Upper gastrointestinal tract

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

There are few data concerning patients with Crohn's disease (CD) complicated by a stricture of the upper gastrointestinal tract (UGT). We evaluated the outcome and management of CD patients complicated by a stricture of ...
Show more >There are few data concerning patients with Crohn's disease (CD) complicated by a stricture of the upper gastrointestinal tract (UGT). We evaluated the outcome and management of CD patients complicated by a stricture of the UGT. We performed a retrospective multicenter study including all CD patients with a non-passable symptomatic UGT stricture on endoscopy. Primary outcome measure was surgery-free survival from diagnosis of stricture. Efficacy of medical, endoscopic, and surgical treatments, and identification of predictors of surgery were also evaluated. 60 CD patients with an UGT stricture were included. 60% of the strictures were located in the duodenum. With a median follow-up of 5.5 (IQR: 3.0-12.0) years since stricture diagnosis, surgical-free survival was 75% and 64% at 1 and 5 years, respectively. At the end of the follow up, 27 (45%) patients underwent surgery. 77 endoscopic procedures were performed in 30 patients with an immediate success of 81% and a clinical benefit in 84% of the procedures. In multivariate analysis, anti-TNF treatment initiation was associated with a reduced risk of surgery. CD UGT strictures are mainly located in the duodenum. Medical and endoscopic treatments allow to avoid surgery in half of the patients.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:48:22Z
2024-02-01T14:05:05Z