Titre :

An initial report from the french sot covid registry suggests high mortality due to covid-19 in recipients of kidney transplants

Auteur(s) :

Caillard, Sophie [Auteur]
Anglicheau, Dany [Auteur]
Matignon, Marie [Auteur]
Durrbach, Antoine [Auteur]
Greze, Clarisse [Auteur]
Frimat, Luc [Auteur]
Thaunat, Olivier [Auteur]
Legris, Tristan [Auteur]
Moal, Valerie [Auteur]
Westeel, Pierre-Francois [Auteur]
Kamar, Nassim [Auteur]
Gatault, Philippe [Auteur]
Snanoudj, Renaud [Auteur]
Sicard, Antoine [Auteur]
Bertrand, Dominique [Auteur]
Colosio, Charlotte [Auteur]
Couzi, Lionel [Auteur]
Chemouny, Jonathan M. [Auteur]
Masset, Christophe [Auteur]
Blancho, Gilles [Auteur]
Bamoulid, Jamal [Auteur]
Duveau, Agnes [Auteur]
Bouvier, Nicolas [Auteur]
Chavarot, Nathalie [Auteur]
Grimbert, Philippe [Auteur]
Moulin, Bruno [Auteur]
Le Meur, Yannick [Auteur]
Hazzan, Marc [Auteur]

Titre de la revue :

Kidney International

Nom court de la revue :

Kidney Int.

Date de publication :

2020-08-24

ISSN :

1523-1755

Mot(s)-clé(s) :

COVID-19
kidney transplantation
mortality
prognosis
immunosuppression

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim of this registry-based observational ...
Lire la suite >Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim of this registry-based observational study was to explore characteristics and clinical outcomes of recipients of kidney transplants included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19. Covid-19 was diagnosed in symptomatic patients who had a positive PCR assay for SARS-CoV-2 or having typical lung lesions on imaging. Clinical and laboratory characteristics, management of immunosuppression, treatment for Covid-19, and clinical outcomes (hospitalization, admission to intensive care unit, mechanical ventilation, or death) were recorded. Risk factors for severe disease or death were determined. Of the 279 patients, 243 were admitted to hospital and 36 were managed at home. The median age of hospitalized patients was 61.6 years; most had comorbidities (hypertension, 90.1%; overweight, 63.8%; diabetes, 41.3%; cardiovascular disease, 36.2%). Fever, cough, dyspnea, and diarrhea were the most common symptoms on admission. Laboratory findings revealed mild inflammation frequently accompanied by lymphopenia. Immunosuppressive drugs were generally withdrawn (calcineurin inhibitors: 28.7%; antimetabolites: 70.8%). Treatment was mainly based on hydroxychloroquine (24.7%), antiviral drugs (7.8%), and tocilizumab (5.3%). Severe Covid-19 occurred in 106 patients (46%). Forty-three hospitalized patients died (30-day mortality 22.8%). Multivariable analysis identified overweight, fever, and dyspnea as independent risk factors for severe disease, whereas age over 60 years, cardiovascular disease, and dyspnea were independently associated with mortality. Thus, Covid-19 in recipients of kidney transplants portends a high mortality rate. Proper management of immunosuppression and tailored treatment of this population remain challenging.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2021-07-06T12:48:41Z