Titre :

Subclinical proximal tubulopathy in hepatitis b: the roles of nucleot(s)ide analogue treatment and the hepatitis b virus

Auteur(s) :

Brayette, Anais [Auteur]
Essig, Marie [Auteur]
Carrier, Paul [Auteur]
Debette-Gratien, Maryline [Auteur]
Labrunie, Anais [Auteur]
Alain, Sophie [Auteur]
Maynard, Marianne [Auteur]
Ganne-Carrie, Nathalie [Auteur]
Nguyen-Khac, Eric [Auteur]
Pinet, Pauline [Auteur]
De Ledinghen, Victor [Auteur]
Renou, Christophe [Auteur]
Mathurin, Philippe [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Vanlemmens, Claire [Auteur]
Di Martino, Vincent [Auteur]
Gervais, Anne [Auteur]
Foucher, Juliette [Auteur]
Isabelle, Fouchard-Hubert [Auteur]
Vergniol, Julien [Auteur]
Ollivier-Hourmand, Isabelle [Auteur]
Cohen, Daniel [Auteur]
Duval, Xavier [Auteur]
Poynard, Thierry [Auteur]
Bardou, Marc [Auteur]
Abergel, Armand [Auteur]
Dao, Manh-Thong [Auteur]
Thevenot, Thierry [Auteur]
Hiriart, Jean-Baptiste [Auteur]
Canva, Valerie [Auteur]
Lassailly, Guillaume [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Aurieres, Christine [Auteur]
Boyer, Nathalie [Auteur]
Thabut, Dominique [Auteur]
Bernard, Pierre-Henri [Auteur]
Schnee, Matthieu [Auteur]
Larrey, Dominique [Auteur]
Hanslik, Bertrand [Auteur]
Hommel, Severine [Auteur]
Jacques, Jeremie [Auteur]
Loustaud-Ratti, Veronique [Auteur]

Titre de la revue :

World journal of hepatology

Nom court de la revue :

World J Hepatol

Numéro :

12

Pagination :

1326-1340

Date de publication :

2020-12-27

ISSN :

1948-5182

Mot(s)-clé(s) :

Renal insufficiency
Biomarkers
Proximal tubulopathy
Hepatitis B virus
Nucleoside analogues

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

BACKGROUND: The recommended monitoring tools for evaluating nucleot(s)ide analogue renal toxicity, such as estimated glomerular filtration rate (eGFR) and phosphatemia, are late markers of proximal tubulopathy. Multiple ...
Lire la suite >BACKGROUND: The recommended monitoring tools for evaluating nucleot(s)ide analogue renal toxicity, such as estimated glomerular filtration rate (eGFR) and phosphatemia, are late markers of proximal tubulopathy. Multiple early markers are available, but no consensus exists on their use. OBJECTIVE: To determine the 24 mo prevalence of subclinical proximal tubulopathy (SPT), as defined with early biomarkers, in treated vs METHODS: A prospective, non-randomized, multicenter study of HBV-monoinfected patients with a low number of renal comorbidities was conducted. The patients were separated into three groups: Naïve, starting entecavir (ETV) treatment, or starting tenofovir disoproxil (TDF) treatment. Data on the early markers of SPT, the eGFR and phosphatemia, were collected quarterly. SPT was defined as a maximal tubular reabsorption of phosphate/eGFR below 0.8 mmoL/L and/or uric acid fractional excretion above 10%. The prevalence and cumulative incidence of SPT at month 24 (M24) were calculated. Quantitative data were analyzed using analyses of variance or Kruskal-Wallis tests, whereas chi-squared or Fisher's exact tests were used to analyze qualitative data. Multivariate analyses were used to adjust for any potential confounding factors. RESULTS: Of the 196 patients analyzed, 138 (84 naïve, 28 starting ETV, and 26 starting TDF) had no SPT at inclusion. At M24, the prevalence of SPT was not statistically different between naïve and either treated group (21.1% vsP <vsPvsP CONCLUSIONS: The prevalence and incidence of SPT was higher in TDF-treated patients compared to naïve patients. SPT in the naïve population suggests that HBV can induce renal tubular toxicity.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2021-07-06T12:49:02Z