Titre :

Impact of preoperative enteral nutritional support on postoperative outcome in patients with crohn's disease complicated by malnutrition. Results of a subgroup analysis of the nationwide cohort registry from the getaid chirurgie group

Auteur(s) :

Abdalla, Solafah [Auteur]
Benoist, Stephane [Auteur]
Histoire Archéologie Littératures des Mondes Anciens (HALMA) - UMR 8164
Maggiori, Leon [Auteur]
Zerbib, Philippe [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lefevre, Jérémie H. [Auteur]
Denost, Quentin [Auteur]
Germain, Adeline [Auteur]
Cotte, Eddy [Auteur]
Beyer-Berjot, Laura [Auteur]
Corte, Helene [Auteur]
Desfourneaux, Véronique [Auteur]
Rahili, Amine [Auteur]
Duffas, Jean-Pierre [Auteur]
Pautrat, Karine [Auteur]
Denet, Christine [Auteur]
Bridoux, Valérie [Auteur]
Meurette, Guillaume [Auteur]
Faucheron, Jean-Luc [Auteur]
Loriau, Jérôme [Auteur]
Guillon, Francoise [Auteur]
Vicaut, Éric [Auteur]
Panis, Yves [Auteur]
Brouquet, Antoine [Auteur]

Titre de la revue :

Colorectal disease . the official journal of the Association of Coloproctology of Great Britain and Ireland

Nom court de la revue :

Colorectal Dis

Date de publication :

2021-02-23

ISSN :

1463-1318

Mot(s)-clé(s) :

malnutrition
Crohn's disease
preoperative enteral nutritional support
postoperative morbidity
inflammatory bowel diseases

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

OBJECTIVE: Postoperative morbidity is high in patients operated on for Crohn's disease (CD) complicated by malnutrition. This study aimed to evaluate the impact of preoperative enteral nutritional support (PENS) on ...
Lire la suite >OBJECTIVE: Postoperative morbidity is high in patients operated on for Crohn's disease (CD) complicated by malnutrition. This study aimed to evaluate the impact of preoperative enteral nutritional support (PENS) on postoperative outcome in patients with CD complicated by malnutrition included in a prospective nationwide cohort. METHODS: Malnutrition was defined as body mass index <18 kg/m2 RESULTS: Among 592 patients included, 149 were selected. In the intention-to-treat population including 20 (13.4%) patients with PENS failure after PSM, 78 'upfront surgery' and 71 'PENS'-matched patients were compared, with no significant difference in the primary endpoint. Perforating CD and preoperative intra-abdominal fistula were associated with PENS failure [37.5 vs 16.1% (P = 0.047) and 41.2% vs 16.2% (P = 0.020), respectively]. After exclusion of these 20 patients, PSM was used to compare 45 'upfront surgery' and 51 'PENS'-matched patients, with a significantly decreased rate of intra-abdominal septic complications and/or temporary defunctioning stoma in the PENS group (19.6 vs 42.2%, P = 0.016). CONCLUSIONS: Preoperative enteral nutritional support is associated with a trend but no conclusive evidence of a reduction in intra-abdominal septic complications and/or requirement for defunctioning stoma. Patients with perforating CD complicated with malnutrition are at risk of PENS failure.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Ministère de la Culture
Université de Lille

Collections :

• Histoire Archéologie Littératures des Mondes Anciens (HALMA) - UMR 8164
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2021-07-06T12:50:03Z