Title :

Living kidney donor evaluation for all candidates with normal estimated gfr for age

Author(s) :

Gaillard, Francois [Auteur]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Jacquemont, Lola [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Lazareth, Helene [Auteur]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Albano, Laetitia [Auteur]
Département de Néphrologie - Hôpital Pasteur [Nice]
Barrou, Benoit [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Bouvier, Nicolas [Auteur]
Hôpital Côte de Nacre [CHU Caen]
Buchler, Mathias [Auteur]
CHU Trousseau [Tours]
Titeca-Beauport, Dimitri [Auteur]
Service de Néphrologie-Dialyse-Transplantation [CHU Amiens-Picardie]
Couzi, Lionel [Auteur]
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Delahousse, Michel [Auteur]
Hôpital Foch [Suresnes]
Ducloux, Didier [Auteur]
Service de Néphrologie [CHRU Besançon]
Etienne, Isabelle [Auteur]
CHU Rouen
Service de néphrologie [Rennes]
Frimat, Luc [Auteur]
Service de Néphrologie [CHRU Nancy]
Garrouste, Cyril [Auteur]
Service Néphrologie, Hémodialyses [CHU Clermont-Ferrand]
Glotz, Denis [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Grimbert, Philippe [Auteur]
IMRB - I-BIOT/"Immunorégulation et Biothérapie" [Créteil] [U955 Inserm - UPEC]
Hazzan, Marc [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Hertig, Alexandre [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Hourmant, Maryvonne [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Kamar, Nassim [Auteur]
Centre de Physiopathologie Toulouse Purpan [CPTP]
Université Toulouse III - Paul Sabatier [UT3]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Le Meur, Yann [Auteur]
CHRU Brest - Service de Nephrologie [CHU - BREST - Nephrologie]
Le Quintrec, Moglie [Auteur]
Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
Hôpital Lapeyronie [CHU Montpellier]
Legendre, Christophe [Auteur]
Service Néphrologie et transplantation rénale Adultes [CHU Necker]
Moal, Valerie [Auteur]
Assistance Publique - Hôpitaux de Marseille [APHM]
Moulin, Bruno [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Mousson, Christiane [Auteur]
Service de néphrologie (CHU de Dijon)
Pouteil-Noble, Claire [Auteur]
Hospices Civils de Lyon [HCL]
Rieu, Philippe [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Ouali, Nacera [Auteur]
CHU Tenon [AP-HP]
Rostaing, Lionel [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Thierry, Antoine [Auteur]
Ischémie reperfusion, métabolisme et inflammation stérile en transplantation [U 1313] [IRMETIST [Poitiers]]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Toure, Fatouma [Auteur]
CHU Limoges
Chemouny, Jonathan M. [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Delanaye, Pierre [Auteur]
Hôpital Universitaire Carémeau [Nîmes] [CHU Nîmes]
Centre Hospitalier Universitaire de Liège [CHU-Liège]
Université de Liège
Courbebaisse, Marie [Auteur]
Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Mariat, Christophe [Auteur]
Service de Néphrologie [CHU Saint Etienne]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]

Journal title :

Transplant International

Abbreviated title :

Transpl Int

Publication date :

2021-03-27

ISSN :

1432-2277

Keyword(s) :

screening
estimated GFR
age
living kidney donors
post&#8208
donation GFR

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Multiple days assessments are frequent for the evaluation of candidates to living kidney donation, combined with an early GFR estimation (eGFR). Living kidney donation is questionable when eGFR is <90 ml/min/1.73 m2 ...
Show more >Multiple days assessments are frequent for the evaluation of candidates to living kidney donation, combined with an early GFR estimation (eGFR). Living kidney donation is questionable when eGFR is <90 ml/min/1.73 m2 (KDIGO guidelines) or 80 ml/min/1.73 m2 (most US centres). However, age-related GFR decline results in a lower eGFR for older candidates. That may limit the number of older kidney donors. Yet, continuing the screening with a GFR measure increases the number of eligible donors. We hypothesized that in-depth screening should be proposed to all candidates with a normal eGFR for age. We compared the evolution of eGFR after donation between three groups of predonation eGFR: normal for age (Sage) higher than 90 or 80 ml/min/1.73 m2 (S90 and S80, respectively); across three age groups (<45, 45-55, >55 years) in a population of 1825 French living kidney donors with a median follow-up of 5.9 years. In donors younger than 45, postdonation eGFR, absolute- and relativeeGFR variation were not different between the three groups. For older donors, postdonation eGFR was higher in S90 than in S80 or Sage but other comparators were identical. eGFR slope was comparable between all groups. Our results are in favour of in-depth screening for all candidates to donation with a normal eGFR for age.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:50:56Z
2024-03-04T09:16:47Z