Title :

Comorbidities are associated with fibrosis in nafld subjects: a nationwide study (nash-co study)

Author(s) :

Nabi, Oumarou [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Boursier, Jerome [Auteur]
Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques [HIFIH]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Université d'Angers [UA]
Lacombe, Karine [Auteur]
CHU Saint-Antoine [AP-HP]
Sorbonne Université [SU]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Mathurin, Philippe [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
De Ledinghen, Victor [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Service d'Hépato-Gastro-Entérologie
Bordeaux Research In Translational Oncology [Bordeaux] [BaRITOn]
Goldberg, Marcel [Auteur]
Université de Versailles Saint-Quentin-en-Yvelines [UVSQ]
Cohortes épidémiologiques en population [CONSTANCES]
Zins, Marie [Auteur]
Université de Versailles Saint-Quentin-en-Yvelines [UVSQ]
Cohortes épidémiologiques en population [CONSTANCES]
Serfaty, Lawrence [Auteur]
Centre de Recherche Saint-Antoine [CRSA]

Journal title :

Digestive Diseases and Sciences

Abbreviated title :

Dig Dis Sci

Publication date :

2021-05-24

ISSN :

1573-2568

Keyword(s) :

Chronic kidney disease
Colorectal cancer
Forns Index
Cancer
Cardiovascular disease
Fatty Liver Index

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: The relationship between the severity of NAFLD and extra-hepatic events such as cardiovascular disease (CVD), extra-hepatic cancer (EHC) or chronic kidney diseases (CKD) has not been clearly investigated in the ...
Show more >BACKGROUND: The relationship between the severity of NAFLD and extra-hepatic events such as cardiovascular disease (CVD), extra-hepatic cancer (EHC) or chronic kidney diseases (CKD) has not been clearly investigated in the general population. OBJECTIVE: The aim of this study was to assess whether the severity of fibrosis in NAFLD subjects was associated with extra-hepatic diseases based on noninvasive markers in a large population-based cohort. METHODS: The study population included a cohort of 118,664 participants from the nationwide CONSTANCES cohort. After excluding individuals with excessive alcohol consumption and other causes of liver disease, 102,344 were included. The noninvasive diagnosis of NAFLD and fibrosis was performed using a combination of the Fatty Liver Index (FLI) and the Forns Index. The history of CVD or EHC was recorded by a physician, and CKD was defined by a glomerular filtration rate < 60 ml/mn. RESULTS: The prevalence of NAFLD (FLI > 60) was 18.2%, 10% with mild fibrosis (Forns Index < 4.2), 7.7% with intermediate fibrosis (Forns Index 4.2-6.9), and 0.4% with advanced fibrosis (Forns Index > 6.9). The prevalence of CVD, EHC, or CKD increased significantly with the severity of fibrosis (p < 0.0001). When adjusted for demographic, metabolic risk factors, and smoking, NAFLD with intermediate or advanced fibrosis remained associated with CVD (OR 1.36, p < 0.0001 and OR 3.07, p < 0.0001, respectively), EHC (OR 1.24, p = 0.001 and OR 1.64, p = 0.004, respectively), and CKD (OR 1.18, p = 0.03 and OR 2.09, p < 0.0001, respectively). CONCLUSIONS: In a large adult population-based cohort, there is a dose-dependent relationship between the severity of fibrosis and CVD, EHC, or CKD in NAFLD subjects.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:50:58Z
2024-03-05T11:13:57Z