Title :

Liver transplantation for hepatocellular carcinoma: a real-life comparison of milan criteria and afp model

Author(s) :

Brusset, Bleuenn [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Université Grenoble Alpes - UFR Médecine [UGA UFRM]
Dumortier, Jerome [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Cherqui, Daniel [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Pageaux, Georges-Philippe [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Boleslawski, Emmanuel [Auteur]
Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189
Chapron, Ludivine [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Quesada, Jean-Louis [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Radenne, Sylvie [Auteur]
Hôpital de la Croix-Rousse [CHU - HCL]
Samuel, Didier [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Navarro, Francis [Auteur]
CHU Montpellier = Montpellier University Hospital
Dharancy, Sebastien [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Decaens, Thomas [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Université Grenoble Alpes [UGA]
Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]

Journal title :

Cancers

Abbreviated title :

Cancers

Volume number :

13

Publication date :

2021-05-01

Keyword(s) :

liver transplantation
hepatocellular carcinoma
AFP model
Milan criteria
post-transplant recurrence

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: To compare the agreement for the criteria on the explant and the results of liver transplantation (LT) before and after adoption of the AFP (α-fetoprotein) model. METHODS: 523 patients consecutively listed in ...
Show more >OBJECTIVE: To compare the agreement for the criteria on the explant and the results of liver transplantation (LT) before and after adoption of the AFP (α-fetoprotein) model. METHODS: 523 patients consecutively listed in five French centers were reviewed to compare results of the Milan criteria period (MilanCP, nn RESULTS: During AFPscP, there was a significantly longer waiting time on the list (12.3 vs. 7.7 months, ppppppp CONCLUSIONS: Agreement for the AFP model on explant analysis (≤2) did not significantly change. AFP score > 2 was the major prognostic factor for recurrence. Graft allocation policy has a major impact on prognosis, with a post-listing OS significantly decreased, probably due to the increase in waiting time, increase in bridging therapies, downstaging policy and salvage transplantation.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189

Submission date :

2021-07-06T12:51:03Z
2024-03-05T10:56:56Z
2024-03-14T10:09:59Z