Pulmonary infections complicating ARDS
Document type :
Article dans une revue scientifique
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Title :
Pulmonary infections complicating ARDS
Author(s) :
Luyt, Charles-Edouard [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
Bouadma, Lila [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Morris, Andrew Conway [Auteur]
University of Cambridge [UK] [CAM]
Dhanani, Jayesh A. [Auteur]
The University of Queensland [UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations]]
Kollef, Marin [Auteur]
Lipman, Jeffrey [Auteur]
The University of Queensland [UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations]]
Martin-Loeches, Ignacio [Auteur]
Trinity College Dublin
Nseir, Saad [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Ranzani, Otavio T. [Auteur]
Universidade Federal de São Paulo
Roquilly, Antoine [Auteur]
Thérapeutiques cliniques et expérimentales des infections (EA 3826) [EA 3826]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Schmidt, Matthieu [Auteur]
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
Institut de cardiologie [CHU Pitié-Salpêtrière]
Torres, Antoni [Auteur]
Universitat de Barcelona [UB]
Timsit, Jean-François [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
CHU Pitié-Salpêtrière [AP-HP]
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
Bouadma, Lila [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Morris, Andrew Conway [Auteur]
University of Cambridge [UK] [CAM]
Dhanani, Jayesh A. [Auteur]
The University of Queensland [UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations]]
Kollef, Marin [Auteur]
Lipman, Jeffrey [Auteur]
The University of Queensland [UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations]]
Martin-Loeches, Ignacio [Auteur]
Trinity College Dublin
Nseir, Saad [Auteur]

Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Ranzani, Otavio T. [Auteur]
Universidade Federal de São Paulo
Roquilly, Antoine [Auteur]
Thérapeutiques cliniques et expérimentales des infections (EA 3826) [EA 3826]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Schmidt, Matthieu [Auteur]
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
Institut de cardiologie [CHU Pitié-Salpêtrière]
Torres, Antoni [Auteur]
Universitat de Barcelona [UB]
Timsit, Jean-François [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Journal title :
Intensive Care Medicine
Abbreviated title :
Intensive Care Med
Volume number :
46
Pages :
2168-2183
Publisher :
Springer Science and Business Media LLC
Publication date :
2020-11-11
English keyword(s) :
Acute respiratory distress syndrome
Ventilator-associated pneumonia
Microbiota
Prevention
Nebulization
Ventilator-associated pneumonia
Microbiota
Prevention
Nebulization
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Pulmonary infection is one of the main complications occurring in patients suffering from acute respiratory distress syndrome (ARDS). Besides traditional risk factors, dysregulation of lung immune defenses and microbiota ...
Show more >Pulmonary infection is one of the main complications occurring in patients suffering from acute respiratory distress syndrome (ARDS). Besides traditional risk factors, dysregulation of lung immune defenses and microbiota may play an important role in ARDS patients. Prone positioning does not seem to be associated with a higher risk of pulmonary infection. Although bacteria associated with ventilator-associated pneumonia (VAP) in ARDS patients are similar to those in patients without ARDS, atypical pathogens (Aspergillus, herpes simplex virus and cytomegalovirus) may also be responsible for infection in ARDS patients. Diagnosing pulmonary infection in ARDS patients is challenging, and requires a combination of clinical, biological and microbiological criteria. The role of modern tools (e.g., molecular methods, metagenomic sequencing, etc.) remains to be evaluated in this setting. One of the challenges of antimicrobial treatment is antibiotics diffusion into the lungs. Although targeted delivery of antibiotics using nebulization may be interesting, their place in ARDS patients remains to be explored. The use of extracorporeal membrane oxygenation in the most severe patients is associated with a high rate of infection and raises several challenges, diagnostic issues and pharmacokinetics/pharmacodynamics changes being at the top. Prevention of pulmonary infection is a key issue in ARDS patients, but there is no specific measure for these high-risk patients. Reinforcing preventive measures using bundles seems to be the best option.Show less >
Show more >Pulmonary infection is one of the main complications occurring in patients suffering from acute respiratory distress syndrome (ARDS). Besides traditional risk factors, dysregulation of lung immune defenses and microbiota may play an important role in ARDS patients. Prone positioning does not seem to be associated with a higher risk of pulmonary infection. Although bacteria associated with ventilator-associated pneumonia (VAP) in ARDS patients are similar to those in patients without ARDS, atypical pathogens (Aspergillus, herpes simplex virus and cytomegalovirus) may also be responsible for infection in ARDS patients. Diagnosing pulmonary infection in ARDS patients is challenging, and requires a combination of clinical, biological and microbiological criteria. The role of modern tools (e.g., molecular methods, metagenomic sequencing, etc.) remains to be evaluated in this setting. One of the challenges of antimicrobial treatment is antibiotics diffusion into the lungs. Although targeted delivery of antibiotics using nebulization may be interesting, their place in ARDS patients remains to be explored. The use of extracorporeal membrane oxygenation in the most severe patients is associated with a high rate of infection and raises several challenges, diagnostic issues and pharmacokinetics/pharmacodynamics changes being at the top. Prevention of pulmonary infection is a key issue in ARDS patients, but there is no specific measure for these high-risk patients. Reinforcing preventive measures using bundles seems to be the best option.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CNRS
Research team(s) :
Glycobiology in fungal Pathogenesis and Clinical Applications
Submission date :
2021-07-15T08:17:41Z
2021-08-23T12:02:51Z
2021-08-23T12:02:51Z
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