Titre :

Thyroid Storm in the ICU

Auteur(s) :

Bourcier, Simon [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Coutrot, Maxime [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Kimmoun, Antoine [Auteur]
Sonneville, Romain [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
de Montmollin, Etienne [Auteur]
Hôpital Delafontaine
Persichini, Romain [Auteur]
Centre Hospitalier Universitaire de La Réunion [CHU La Réunion]
Schnell, David [Auteur]
Centre Hospitalier d'Angoulême [CH Angoulême]
Charpentier, Julien [Auteur]
AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris]
Aubron, Cécile [Auteur]
Centre Hospitalier Régional Universitaire de Brest [CHRU Brest]
Morawiec, Elise [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Bigé, Naïke [Auteur]
CHU Saint-Antoine [AP-HP]
Nseir, Saad [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Terzi, Nicolas [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Razazi, Keyvan [Auteur]
CHU Henri Mondor [Créteil]
Azoulay, Elie [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Ferré, Alexis [Auteur]
Centre Hospitalier de Versailles André Mignot [CHV]
Tandjaoui-Lambiotte, Yacine [Auteur]
Hôpital Avicenne [AP-HP]
Ellrodt, Olivier [Auteur]

Hraiech, Sami [Auteur]
Hôpital Nord [CHU - APHM]
Delmas, Clément [Auteur]

Barbier, François [Auteur]
Centre Hospitalier Régional d'Orléans [CHRO]
Lautrette, Alexandre [Auteur]
CHU Clermont-Ferrand
Aissaoui, Nadia [Auteur]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Repessé, Xavier [Auteur]
Hôpital Ambroise Paré [AP-HP]
Pichereau, Claire [Auteur]
Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy]
Zerbib, Yoann [Auteur]
CHU Amiens-Picardie
Lascarrou, Jean-Baptiste [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Carreira, Serge [Auteur]
Reuter, Danielle [Auteur]
Frérou, Aurélien [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Peigne, Vincent [Auteur]
Centre Hospitalier Métropole Savoie [Chambéry]
Fillatre, Pierre [Auteur]

Megarbane, Bruno [Auteur]
Hôpital Lariboisière-Fernand-Widal [APHP]
Voiriot, Guillaume [Auteur]
CHU Tenon [AP-HP]
Combes, Alain [Auteur]
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
Schmidt, Matthieu [Auteur]
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]

Titre de la revue :

Critical Care Medicine

Nom court de la revue :

Critical Care Medicine

Numéro :

48

Pagination :

83-90

Éditeur :

Ovid Technologies (Wolters Kluwer Health)

Date de publication :

2020-01

ISSN :

0090-3493

Mot(s)-clé(s) en anglais :

cardiogenic shock
critical care
extracorporeal membrane oxygenation
hyperthyroidism
thyroid crisis
thyrotoxicosis

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Objectives: Thyroid storm represents a rare but life-threatening endocrine emergency. Only rare data are available on its management and the outcome of the most severe forms requiring ICU admission. We aimed to describe ...
Lire la suite >Objectives: Thyroid storm represents a rare but life-threatening endocrine emergency. Only rare data are available on its management and the outcome of the most severe forms requiring ICU admission. We aimed to describe the clinical manifestations, management and in-ICU and 6-month survival rates of patients with those most severe thyroid storm forms requiring ICU admission. Design: Retrospective, multicenter, national study over an 18-year period (2000–2017). Setting: Thirty-one French ICUs. Patients: The local medical records of patients from each participating ICU were screened using the International Classification of Diseases, 10th Revision. Inclusion criteria were “definite thyroid storm,” as defined by the Japanese Thyroid Association criteria, and at least one thyroid storm-related organ failure. Measurements and Main Results: Ninety-two patients were included in the study. Amiodarone-associated thyrotoxicosis and Graves’ disease represented the main thyroid storm etiologies (30 [33%] and 24 [26%] patients, respectively), while hyperthyroidism was unknown in 29 patients (32%) before ICU admission. Amiodarone use (24 patients [26%]) and antithyroid-drug discontinuation (13 patients [14%]) were the main thyroid storm-triggering factors. No triggering factor was identified for 30 patients (33%). Thirty-five patients (38%) developed cardiogenic shock within the first 48 hours after ICU admission. In-ICU and 6-month postadmission mortality rates were 17% and 22%, respectively. ICU nonsurvivors more frequently required vasopressors, extracorporeal membrane of oxygenation, renal replacement therapy, mechanical ventilation, and/or therapeutic plasmapheresis. Multivariable analyses retained Sequential Organ Failure Assessment score without cardiovascular component (odds ratio, 1.22; 95% CI, 1.03–1.46; p = 0.025) and cardiogenic shock within 48 hours post-ICU admission (odds ratio, 9.43; 1.77–50.12; p = 0.008) as being independently associated with in-ICU mortality. Conclusions: Thyroid storm requiring ICU admission causes high in-ICU mortality. Multiple organ failure and early cardiogenic shock seem to markedly impact the prognosis, suggesting a prompt identification and an aggressive management.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Équipe(s) de recherche :

Glycobiology in fungal Pathogenesis and Clinical Applications

Date de dépôt :

2021-07-15T08:25:03Z
2021-08-23T11:25:13Z