International Survey to Establish Prioritized ...
Type de document :
Article dans une revue scientifique
URL permanente :
Titre :
International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019
Auteur(s) :
Evangelidis, Nicole [Auteur]
The University of Sydney
Tong, Allison [Auteur]
The University of Sydney
Howell, Martin [Auteur]
The University of Sydney
Teixeira-Pinto, Armando [Auteur]
The University of Sydney
Elliott, Julian H. [Auteur]
Monash University [Melbourne]
Azevedo, Luciano Cesar [Auteur]
Bersten, Andrew [Auteur]
Flinders University [Adelaide, Australia]
Cervantes, Lilia [Auteur]
Chew, Derek P. [Auteur]
Flinders University [Adelaide, Australia]
Crowe, Sally [Auteur]
Douglas, Ivor S. [Auteur]
University of Colorado [Denver]
Flemyng, Ella [Auteur]
Horby, Peter [Auteur]
University of Oxford
Lee, Jaehee [Auteur]
Kyungpook National University [Daegu] [KNU]
Lorca, Eduardo [Auteur]
Universidad de Chile = University of Chile [Santiago] [UCHILE]
Lynch, Deena [Auteur]
Marshall, John C. [Auteur]
University of Toronto
McKenzie, Anne [Auteur]
Mehta, Sangeeta [Auteur]
University of Toronto
Mer, Mervyn [Auteur]
University of the Witwatersrand [Johannesburg] [WITS]
Morris, Andrew Conway [Auteur]
University of Cambridge [UK] [CAM]
Nseir, Saad [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Povoa, Pedro [Auteur]
Universidade Nova de Lisboa = NOVA University Lisbon [NOVA]
Reid, Mark [Auteur]
Sakr, Yasser [Auteur]
Jena University Hospital [Jena]
Shen, Ning [Auteur]
Smyth, Alan R. [Auteur]
University of Nottingham, UK [UON]
Snelling, Tom [Auteur]
The University of Sydney
Strippoli, Giovanni F. M. [Auteur]
Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro [UNIBA]
Torres, Antoni [Auteur]
Institut d'Investigacions Biomèdiques August Pi i Sunyer [IDIBAPS]
Centro de Investigación Biomédica en Red Enfermedades Respiratorias [CIBERES]
Turner, Tari [Auteur]
Monash University [Melbourne]
Webb, Steve [Auteur]
Monash University [Melbourne]
Williamson, Paula R. [Auteur]
University of Liverpool
Woc-Colburn, Laila [Auteur]
Baylor College of Medecine
Zhang, Junhua [Auteur]
Tianjin University [TJU]
Baumgart, Amanda [Auteur]
The University of Sydney
Cabrera, Sebastian [Auteur]
Universidad de Chile = University of Chile [Santiago] [UCHILE]
Cho, Yeoungjee [Auteur]
The University of Queensland [UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations]]
Cooper, Tess [Auteur]
The University of Sydney
Guha, Chandana [Auteur]
The University of Sydney
Liu, Emma [Auteur]
The University of Sydney
Gonzalez, Andrea Matus [Auteur]
The University of Sydney
McLeod, Charlie [Auteur]
Natale, Patrizia [Auteur]
Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro [UNIBA]
Saglimbene, Valeria [Auteur]
Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro [UNIBA]
Viecelli, Andrea K. [Auteur]
The University of Queensland [UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations]]
Craig, Jonathan C. [Auteur]
Flinders University [Adelaide, Australia]
The University of Sydney
Tong, Allison [Auteur]
The University of Sydney
Howell, Martin [Auteur]
The University of Sydney
Teixeira-Pinto, Armando [Auteur]
The University of Sydney
Elliott, Julian H. [Auteur]
Monash University [Melbourne]
Azevedo, Luciano Cesar [Auteur]
Bersten, Andrew [Auteur]
Flinders University [Adelaide, Australia]
Cervantes, Lilia [Auteur]
Chew, Derek P. [Auteur]
Flinders University [Adelaide, Australia]
Crowe, Sally [Auteur]
Douglas, Ivor S. [Auteur]
University of Colorado [Denver]
Flemyng, Ella [Auteur]
Horby, Peter [Auteur]
University of Oxford
Lee, Jaehee [Auteur]
Kyungpook National University [Daegu] [KNU]
Lorca, Eduardo [Auteur]
Universidad de Chile = University of Chile [Santiago] [UCHILE]
Lynch, Deena [Auteur]
Marshall, John C. [Auteur]
University of Toronto
McKenzie, Anne [Auteur]
Mehta, Sangeeta [Auteur]
University of Toronto
Mer, Mervyn [Auteur]
University of the Witwatersrand [Johannesburg] [WITS]
Morris, Andrew Conway [Auteur]
University of Cambridge [UK] [CAM]
Nseir, Saad [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Povoa, Pedro [Auteur]
Universidade Nova de Lisboa = NOVA University Lisbon [NOVA]
Reid, Mark [Auteur]
Sakr, Yasser [Auteur]
Jena University Hospital [Jena]
Shen, Ning [Auteur]
Smyth, Alan R. [Auteur]
University of Nottingham, UK [UON]
Snelling, Tom [Auteur]
The University of Sydney
Strippoli, Giovanni F. M. [Auteur]
Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro [UNIBA]
Torres, Antoni [Auteur]
Institut d'Investigacions Biomèdiques August Pi i Sunyer [IDIBAPS]
Centro de Investigación Biomédica en Red Enfermedades Respiratorias [CIBERES]
Turner, Tari [Auteur]
Monash University [Melbourne]
Webb, Steve [Auteur]
Monash University [Melbourne]
Williamson, Paula R. [Auteur]
University of Liverpool
Woc-Colburn, Laila [Auteur]
Baylor College of Medecine
Zhang, Junhua [Auteur]
Tianjin University [TJU]
Baumgart, Amanda [Auteur]
The University of Sydney
Cabrera, Sebastian [Auteur]
Universidad de Chile = University of Chile [Santiago] [UCHILE]
Cho, Yeoungjee [Auteur]
The University of Queensland [UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations]]
Cooper, Tess [Auteur]
The University of Sydney
Guha, Chandana [Auteur]
The University of Sydney
Liu, Emma [Auteur]
The University of Sydney
Gonzalez, Andrea Matus [Auteur]
The University of Sydney
McLeod, Charlie [Auteur]
Natale, Patrizia [Auteur]
Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro [UNIBA]
Saglimbene, Valeria [Auteur]
Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro [UNIBA]
Viecelli, Andrea K. [Auteur]
The University of Queensland [UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations]]
Craig, Jonathan C. [Auteur]
Flinders University [Adelaide, Australia]
Titre de la revue :
Critical Care Medicine
Numéro :
48
Pagination :
1612-1621
Éditeur :
Ovid Technologies (Wolters Kluwer Health)
Date de publication :
2020-08-18
ISSN :
0090-3493
Mot(s)-clé(s) en anglais :
clinical trial
coronavirus
critical care
infection
patients
sepsis
coronavirus
critical care
infection
patients
sepsis
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Objectives:
There are over 4,000 trials conducted in people with coronavirus disease 2019. However, the variability of outcomes and the omission of patient-centered outcomes may diminish the impact of these trials on ...
Lire la suite >Objectives: There are over 4,000 trials conducted in people with coronavirus disease 2019. However, the variability of outcomes and the omission of patient-centered outcomes may diminish the impact of these trials on decision-making. The aim of this study was to generate a consensus-based, prioritized list of outcomes for coronavirus disease 2019 trials. Design: In an online survey conducted in English, Chinese, Italian, Portuguese, and Spanish languages, adults with coronavirus disease 2019, their family members, health professionals, and the general public rated the importance of outcomes using a 9-point Likert scale (7–9, critical importance) and completed a Best-Worst Scale to estimate relative importance. Participant comments were analyzed thematically.Setting: International. Subjects: Adults 18 years old and over with confirmed or suspected coronavirus disease 2019, their family members, members of the general public, and health professionals (including clinicians, policy makers, regulators, funders, and researchers). Interventions: None. Measurements: None. Main Results: In total, 9,289 participants from 111 countries (776 people with coronavirus disease 2019 or family members, 4,882 health professionals, and 3,631 members of the public) completed the survey. The four outcomes of highest priority for all three groups were: mortality, respiratory failure, pneumonia, and organ failure. Lung function, lung scarring, sepsis, shortness of breath, and oxygen level in the blood were common to the top 10 outcomes across all three groups (mean > 7.5, median ≥ 8, and > 70% of respondents rated the outcome as critically important). Patients/family members rated fatigue, anxiety, chest pain, muscle pain, gastrointestinal problems, and cardiovascular disease higher than health professionals. Four themes underpinned prioritization: fear of life-threatening, debilitating, and permanent consequences; addressing knowledge gaps; enabling preparedness and planning; and tolerable or infrequent outcomes. Conclusions: Life-threatening respiratory and other organ outcomes were consistently highly prioritized by all stakeholder groups. Patients/family members gave higher priority to many patient-reported outcomes compared with health professionals.Lire moins >
Lire la suite >Objectives: There are over 4,000 trials conducted in people with coronavirus disease 2019. However, the variability of outcomes and the omission of patient-centered outcomes may diminish the impact of these trials on decision-making. The aim of this study was to generate a consensus-based, prioritized list of outcomes for coronavirus disease 2019 trials. Design: In an online survey conducted in English, Chinese, Italian, Portuguese, and Spanish languages, adults with coronavirus disease 2019, their family members, health professionals, and the general public rated the importance of outcomes using a 9-point Likert scale (7–9, critical importance) and completed a Best-Worst Scale to estimate relative importance. Participant comments were analyzed thematically.Setting: International. Subjects: Adults 18 years old and over with confirmed or suspected coronavirus disease 2019, their family members, members of the general public, and health professionals (including clinicians, policy makers, regulators, funders, and researchers). Interventions: None. Measurements: None. Main Results: In total, 9,289 participants from 111 countries (776 people with coronavirus disease 2019 or family members, 4,882 health professionals, and 3,631 members of the public) completed the survey. The four outcomes of highest priority for all three groups were: mortality, respiratory failure, pneumonia, and organ failure. Lung function, lung scarring, sepsis, shortness of breath, and oxygen level in the blood were common to the top 10 outcomes across all three groups (mean > 7.5, median ≥ 8, and > 70% of respondents rated the outcome as critically important). Patients/family members rated fatigue, anxiety, chest pain, muscle pain, gastrointestinal problems, and cardiovascular disease higher than health professionals. Four themes underpinned prioritization: fear of life-threatening, debilitating, and permanent consequences; addressing knowledge gaps; enabling preparedness and planning; and tolerable or infrequent outcomes. Conclusions: Life-threatening respiratory and other organ outcomes were consistently highly prioritized by all stakeholder groups. Patients/family members gave higher priority to many patient-reported outcomes compared with health professionals.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CNRS
CNRS
Équipe(s) de recherche :
Glycobiology in fungal Pathogenesis and Clinical Applications
Date de dépôt :
2021-07-15T09:09:02Z
2021-08-23T12:57:00Z
2021-08-23T12:57:00Z
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