Inhibitory deterioration may contribute ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Inhibitory deterioration may contribute to hallucinations in Alzheimer's disease
Auteur(s) :
El Haj, Mohamad [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Larøi, Frank [Auteur]
GIGA-Neurosciences [Université Liège]
Gély-Nargeot, Marie-Christine [Auteur]
Dynamique des capacités humaines et des conduites de santé [EPSYLON]
Raffard, Stéphane [Auteur]
Dynamique des capacités humaines et des conduites de santé [EPSYLON]
Département de psychiatrie adulte
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Larøi, Frank [Auteur]
GIGA-Neurosciences [Université Liège]
Gély-Nargeot, Marie-Christine [Auteur]
Dynamique des capacités humaines et des conduites de santé [EPSYLON]
Raffard, Stéphane [Auteur]
Dynamique des capacités humaines et des conduites de santé [EPSYLON]
Département de psychiatrie adulte
Titre de la revue :
Cognitive Neuropsychiatry
Nom court de la revue :
Cogn Neuropsychiatry
Numéro :
20
Pagination :
281-295
Date de publication :
2015-03-19
ISSN :
1464-0619
Discipline(s) HAL :
Sciences cognitives
Résumé en anglais : [en]
INTRODUCTION: Although delusions and hallucinations are relatively common symptoms in individuals with Alzheimer's disease (AD), very little is known regarding underlying mechanisms. We examined whether these manifestations ...
Lire la suite >INTRODUCTION: Although delusions and hallucinations are relatively common symptoms in individuals with Alzheimer's disease (AD), very little is known regarding underlying mechanisms. We examined whether these manifestations could be underpinned by psychological distress and executive impairments. METHODS: Thirty-one participants with probable mild AD and 33 healthy older adults were administered a neuropsychological and clinical battery assessing delusions, hallucinations, anxiety, depression, episodic memory and executive functions (shifting, updating and inhibition). RESULTS: Prevalence of delusions and hallucinations were significantly higher in AD participants compared to control participants. Further, hallucinations in AD participants were significantly correlated with poor inhibition, with the latter uniquely predicting the former, as compared to other variables. In addition, hallucinations in AD participants were associated with depression, a relationship that was further mediated by inhibition. CONCLUSION: Hallucinations in individuals with AD seem to be related to difficulties suppressing irrelevant thoughts, resulting in these irrelevant thoughts becoming confused with ongoing reality.Lire moins >
Lire la suite >INTRODUCTION: Although delusions and hallucinations are relatively common symptoms in individuals with Alzheimer's disease (AD), very little is known regarding underlying mechanisms. We examined whether these manifestations could be underpinned by psychological distress and executive impairments. METHODS: Thirty-one participants with probable mild AD and 33 healthy older adults were administered a neuropsychological and clinical battery assessing delusions, hallucinations, anxiety, depression, episodic memory and executive functions (shifting, updating and inhibition). RESULTS: Prevalence of delusions and hallucinations were significantly higher in AD participants compared to control participants. Further, hallucinations in AD participants were significantly correlated with poor inhibition, with the latter uniquely predicting the former, as compared to other variables. In addition, hallucinations in AD participants were associated with depression, a relationship that was further mediated by inhibition. CONCLUSION: Hallucinations in individuals with AD seem to be related to difficulties suppressing irrelevant thoughts, resulting in these irrelevant thoughts becoming confused with ongoing reality.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Date de dépôt :
2019-02-13T14:50:39Z
2020-03-09T10:43:30Z
2020-03-09T10:46:10Z
2020-03-09T10:43:30Z
2020-03-09T10:46:10Z