Sortilin-derived peptides promote pancreatic ...
Type de document :
Compte-rendu et recension critique d'ouvrage
Titre :
Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway
Auteur(s) :
Daziano, Guillaume [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Blondeau, Nicolas [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Béraud-Dufour, Sophie [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Abderrahmani, Amar [Auteur]
NanoBioInterfaces - IEMN [NBI - IEMN]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Rovère, Carole [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Heurteaux, Catherine [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Mazella, Jean [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Lebrun, Patricia [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Coppola, Thierry [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Blondeau, Nicolas [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Béraud-Dufour, Sophie [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Abderrahmani, Amar [Auteur]
NanoBioInterfaces - IEMN [NBI - IEMN]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Rovère, Carole [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Heurteaux, Catherine [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Mazella, Jean [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Lebrun, Patricia [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Coppola, Thierry [Auteur]
Institut de pharmacologie moléculaire et cellulaire [IPMC]
Titre de la revue :
Pharmacological Research
Pagination :
105539
Éditeur :
Elsevier
Date de publication :
2021
ISSN :
1043-6618
Mot(s)-clé(s) en anglais :
Calcium influx
CREB activation
Neuropeptide
Sortilin-released propeptide
Beta-cell protection
CREB activation
Neuropeptide
Sortilin-released propeptide
Beta-cell protection
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Endocrinologie et métabolisme
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biochimie [q-bio.BM]
Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biochimie [q-bio.BM]
Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie
Résumé en anglais : [en]
Deterioration of insulin secretion and pancreatic beta-cell mass by inflammatory attacks is one of the main pathophysiological features of type 2 diabetes (T2D). Therefore, preserving beta-cell mass and stimulating insulin ...
Lire la suite >Deterioration of insulin secretion and pancreatic beta-cell mass by inflammatory attacks is one of the main pathophysiological features of type 2 diabetes (T2D). Therefore, preserving beta-cell mass and stimulating insulin secretion only in response to glucose for avoiding the hypoglycemia risks, are the most state-of-the-art option for the treatment of T2D. In this study we tested two correlated hypothesis that 1/ the endogenous peptide released from sortilin, known as PE, that stimulates insulin secretion only in response to glucose, protects beta-cells against death induced by cytokines, and 2/ Spadin and Mini-Spadin, two synthetic peptides derived from PE, that mimic the effects of PE in insulin secretion, also provide beneficial effect on beta-cells survival. We show that PE and its derivatives by inducing a rise of intracellular calcium concentration by depolarizing the membrane protect beta-cells against death induced by Interleukin-1β. Using biochemical, confocal imaging and cell biology techniques, we reveal that the protective effects of PE and its derivatives rely on the activation of the CaM-Kinase pathway, and on the phosphorylation and activation of the transcription factor CREB. In addition, Mini-Spadin promotes beta-cell proliferation, suggesting its possible regenerative effect. This study highlights new possible roles of PE in pancreatic beta-cell survival and its derivatives as pharmacological tools against diabetes.Lire moins >
Lire la suite >Deterioration of insulin secretion and pancreatic beta-cell mass by inflammatory attacks is one of the main pathophysiological features of type 2 diabetes (T2D). Therefore, preserving beta-cell mass and stimulating insulin secretion only in response to glucose for avoiding the hypoglycemia risks, are the most state-of-the-art option for the treatment of T2D. In this study we tested two correlated hypothesis that 1/ the endogenous peptide released from sortilin, known as PE, that stimulates insulin secretion only in response to glucose, protects beta-cells against death induced by cytokines, and 2/ Spadin and Mini-Spadin, two synthetic peptides derived from PE, that mimic the effects of PE in insulin secretion, also provide beneficial effect on beta-cells survival. We show that PE and its derivatives by inducing a rise of intracellular calcium concentration by depolarizing the membrane protect beta-cells against death induced by Interleukin-1β. Using biochemical, confocal imaging and cell biology techniques, we reveal that the protective effects of PE and its derivatives rely on the activation of the CaM-Kinase pathway, and on the phosphorylation and activation of the transcription factor CREB. In addition, Mini-Spadin promotes beta-cell proliferation, suggesting its possible regenerative effect. This study highlights new possible roles of PE in pancreatic beta-cell survival and its derivatives as pharmacological tools against diabetes.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Projet ANR :
Source :
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- https://doi.org/10.1016/j.phrs.2021.105539
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- https://doi.org/10.1016/j.phrs.2021.105539
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- https://hal.archives-ouvertes.fr/hal-03176756/document
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- https://doi.org/10.1016/j.phrs.2021.105539
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- https://doi.org/10.1016/j.phrs.2021.105539
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- https://doi.org/10.1016/j.phrs.2021.105539
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- https://doi.org/10.1016/j.phrs.2021.105539
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- 2021-Daziano-PE-creb-Pharma-res.pdf
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