Title :

DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge.

Author(s) :

Castillo-Aguilera, Omar [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Depreux, Patrick [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Halby, Ludovic [Auteur]
Arimondo, Paola B [Auteur]
Churchill College [Cambridge]
Goossens, Laurence [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]

Journal title :

Biomolecules

Abbreviated title :

Biomolecules

Volume number :

7

Publication date :

2017-01-05

ISSN :

2218-273X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Chromatin can adopt a decondensed state linked to gene transcription (euchromatin) and a condensed state linked to transcriptional repression (heterochromatin). These states are controlled by epigenetic modulators that are ...
Show more >Chromatin can adopt a decondensed state linked to gene transcription (euchromatin) and a condensed state linked to transcriptional repression (heterochromatin). These states are controlled by epigenetic modulators that are active on either the DNA or the histones and are tightly associated to each other. Methylation of both DNA and histones is involved in either the activation or silencing of genes and their crosstalk. Since DNA/histone methylation patterns are altered in cancers, molecules that target these modifications are interesting therapeutic tools. We present herein a vast panel of DNA methyltransferase inhibitors classified according to their mechanism, as well as selected histone methyltransferase inhibitors sharing a common mode of action.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365

Research team(s) :

Modélisation biopharmaceutique et pharmacocinétique

Submission date :

2019-02-26T17:09:48Z
2021-06-21T09:23:18Z
2021-06-21T09:26:57Z
2021-11-03T09:08:40Z
2022-06-15T12:14:28Z