Dressings Loaded with Cyclodextrin-Hamamelitannin ...
Document type :
Article dans une revue scientifique
DOI :
PMID :
Permalink :
Title :
Dressings Loaded with Cyclodextrin-Hamamelitannin Complexes Increase Staphylococcus aureus Susceptibility Toward Antibiotics Both in Single as well as in Mixed Biofilm Communities
Author(s) :
Brackman, Gilles [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Garcia Fernandez, Maria-Jose [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Lenoir, Joke [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
De Meyer, Laurens [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Remon, Jean-Paul [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
De Beer, Thomas [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Concheiro, Angel [Auteur]
Universidade de Santiago de Compostela [Spain] [USC ]
Alvarez-Lorenzo, Carmen [Auteur]
Universidade de Santiago de Compostela [Spain] [USC ]
Coenye, Tom [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Garcia Fernandez, Maria-Jose [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Lenoir, Joke [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
De Meyer, Laurens [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Remon, Jean-Paul [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
De Beer, Thomas [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Concheiro, Angel [Auteur]
Universidade de Santiago de Compostela [Spain] [USC ]
Alvarez-Lorenzo, Carmen [Auteur]
Universidade de Santiago de Compostela [Spain] [USC ]
Coenye, Tom [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Journal title :
Macromolecular Bioscience
Abbreviated title :
Macromol. Biosci.
Volume number :
16
Pages :
859-869
Publication date :
2016-02
ISSN :
1616-5187
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Bacteria reside within biofilms at the infection site, making them extremely difficult to eradicate with conventional wound care products. Bacteria use quorum sensing (QS) systems to regulate biofilm formation, and QS ...
Show more >Bacteria reside within biofilms at the infection site, making them extremely difficult to eradicate with conventional wound care products. Bacteria use quorum sensing (QS) systems to regulate biofilm formation, and QS inhibitors (QSIs) have been proposed as promising antibiofilm agents. Despite this, few antimicrobial therapies that interfere with QS exist. Nontoxic hydroxypropyl-β-cyclodextrin-functionalized cellulose gauzes releasing a burst of the antibiotic vancomycin and the QSI hamamelitannin are developed, followed by a sustained release of both. The gauzes affect QS and biofilm formation of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro model of chronic wound infection and can be considered as candidates to be used to prevent wound infection as well as treat infected woundsShow less >
Show more >Bacteria reside within biofilms at the infection site, making them extremely difficult to eradicate with conventional wound care products. Bacteria use quorum sensing (QS) systems to regulate biofilm formation, and QS inhibitors (QSIs) have been proposed as promising antibiofilm agents. Despite this, few antimicrobial therapies that interfere with QS exist. Nontoxic hydroxypropyl-β-cyclodextrin-functionalized cellulose gauzes releasing a burst of the antibiotic vancomycin and the QSI hamamelitannin are developed, followed by a sustained release of both. The gauzes affect QS and biofilm formation of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro model of chronic wound infection and can be considered as candidates to be used to prevent wound infection as well as treat infected woundsShow less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Research team(s) :
Modélisation biopharmaceutique et pharmacocinétique
Submission date :
2019-02-26T17:11:47Z
2021-12-15T09:29:04Z
2021-12-15T09:29:04Z