Title :

Protein digestion and energy homeostasis: How generated peptides may impact intestinal hormones?

Author(s) :

Caron, Juliette [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Domenger, Dorothee [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Belguesmia, Yanath [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Kouach, Mostafa [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
LESAGE, JEAN [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Goossens, Jean-Francois [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Dhulster, Pascal [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Ravallec, Rozenn [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Cudennec, Benoit [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]

Journal title :

Food Research International

Abbreviated title :

Food Res. Int.

Volume number :

88

Pages :

310-318

Publication date :

2016

ISSN :

0963-9969

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The aim of the present study is to investigate how peptides released by gastrointestinal (GI) digestion of one dietary protein can interact with regulating processes of food intake. An in vitro GI digestion of bovine ...
Show more >The aim of the present study is to investigate how peptides released by gastrointestinal (GI) digestion of one dietary protein can interact with regulating processes of food intake. An in vitro GI digestion of bovine haemoglobin was carried out and the bioactivity of the digests on CCK and GLP-1 secretion and dipeptidyl peptidase IV (DPP-IV) activity was measured. Intestinal digests exhibited the most potent action on gut hormone release and DPP-IV activity inhibition. They also had the ability to promote hormone gene expression. As a conclusion, two fractions from final intestinal digest led to the greatest GLP-1 secretion increase and DPP-IV activity inhibition. These findings could be very useful in obesity and T2D management research.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille
INRA
ISA
Univ. Artois
Univ. Littoral Côte d’Opale

Collections :

• Environnement Périnatal et Santé - ULR 4489
• Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
• Institut Charles Viollette (ICV) - ULR 7394

Research team(s) :

Modélisation biopharmaceutique et pharmacocinétique

Submission date :

2019-02-26T17:11:52Z
2022-01-19T11:03:23Z