Titre :

One- or Two-Step Synthesis of C-8 and N-9 Substituted Purines

Auteur(s) :

Bollier, Melanie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Klupsch, Frederique [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Six, Perrine [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Dubuquoy, Laurent [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Azaroual, Nathalie [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
MILLET, Régis [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Leleu-Chavain, Natascha [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Titre de la revue :

The Journal of organic chemistry

Nom court de la revue :

J. Org. Chem.

Numéro :

83

Pagination :

422-430

Date de publication :

2018-01-05

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

A novel and original strategy to obtain rapidly a large diversity of C-8 and N-9 substituted purines was developed. The present procedure describes annulation reactions in one or two steps starting from 5-aminoimidazole ...
Lire la suite >A novel and original strategy to obtain rapidly a large diversity of C-8 and N-9 substituted purines was developed. The present procedure describes annulation reactions in one or two steps starting from 5-aminoimidazole-4-carbonitriles 1-8 in moderate to good yields. 8,9-Disubstituted-6,9-dihydro-1H-purin-6-ones 9-14, 6-amino-8,9-disubstituted-3,9-dihydro-2H-purin-2-ones 15-20, 8,9-disubstituted-3,9-dihydro-2H-purin-2,6-diamines 21-24 and 6-imino-1-phenyl-8,9-disubstituted-6,9-dihydro-1H-purin-2-(3H)-ones 25-26 were synthesized in one step using formic acid, urea, guanidine carbonate, and phenylisocyanate, respectively, whereas 8,9-disubstituted-9H-purin-6-amines 27-31 and 6-imino-8,9-disubstituted-6,9-dihydro-1H-purin-1-amines 32-33 were obtained in two steps using formamide and hydrazine, respectively.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille
Inserm

Collections :

• Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Équipe(s) de recherche :

Innovation/évaluation des dispositifs médicaux de perfusion
Therapeutic innovation targetting inflammation

Date de dépôt :

2019-02-26T17:15:44Z
2021-05-27T15:27:01Z
2023-12-13T11:11:35Z