Title :

Gamma Glutamyltransferase Reduction Is Associated With Favorable Outcomes in Pediatric Primary Sclerosing Cholangitis.

Author(s) :

Deneau Mark, R [Auteur]
Mack, Cara [Auteur]
Abdou, Reham [Auteur]
Amin, Mansi [Auteur]
Amir, Achiya [Auteur]
Auth, Marcus [Auteur]
Bazerbachi, Fateh [Auteur]
Marie Broderick, Anne [Auteur]
Chan, Albert [Auteur]
Diguglielmo, Matthew [Auteur]
El-Matary, Wael [Auteur]
El-Youssef, Mounif [Auteur]
Ferrari, Federica [Auteur]
Furuya Katryn, N [Auteur]
gottrand, frederic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Gupta, Nitika [Auteur]
Homan, Matjaz [Auteur]
Jensen M, K [Auteur]
Kamath Binita, M [Auteur]
Mo Kim, Kyung [Auteur]
Kolho, Kaija-Leena [Auteur]
Konidari, Anastasia [Auteur]
Koot, Bart [Auteur]
Iorio, Raffaele [Auteur]
Martinez, Mercedes [Auteur]
Mohan, Parvathi [Auteur]
Palle, Sirish [Auteur]
Papadopoulou, Alexandra [Auteur]
Ricciuto, Amanda [Auteur]
Saubermann, Lawrence [Auteur]
Sathya, Pushpa [Auteur]
Shteyer, Eyal [Auteur]
Smolka, Vratislav [Auteur]
Tanaka, Atsushi [Auteur]
Valentino Pamela, L [Auteur]
Varier, Raghu [Auteur]
Venkat, Veena [Auteur]
Vitola, Bernadette [Auteur]
Vos Miriam, B [Auteur]
Woynarowski, Marek [Auteur]
Yap, Jason [Auteur]
Miloh, Tamir [Auteur]

Journal title :

Hepatol Commun

Abbreviated title :

Hepatol Commun

Volume number :

2

Pages :

1369-1378

Publication date :

2018-11-01

ISSN :

2471-254X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Adverse clinical events in primary sclerosing cholangitis (PSC) happen too slowly to capture during clinical trials. Surrogate endpoints are needed, but no such validated endpoints exist for children with PSC. We evaluated ...
Show more >Adverse clinical events in primary sclerosing cholangitis (PSC) happen too slowly to capture during clinical trials. Surrogate endpoints are needed, but no such validated endpoints exist for children with PSC. We evaluated the association between gamma glutamyltransferase (GGT) reduction and long-term outcomes in pediatric PSC patients. We evaluated GGT normalization (< 50 IU/L) at 1 year among a multicenter cohort of children with PSC who did or did not receive treatment with ursodeoxycholic acid (UDCA). We compared rates of event-free survival (no portal hypertensive or biliary complications, cholangiocarcinoma, liver transplantation, or liver-related death) at 5 years. Of the 287 children, mean age of 11.4 years old, UDCA was used in 81% at a mean dose of 17 mg/kg/day. Treated and untreated groups had similar GGT at diagnosis (314 versus 300, P= not significant [NS]). The mean GGT was reduced at 1 year in both groups, with lower values seen in treated (versus untreated) patients (99 versus 175, P= 0.002), but 5-year event-free survival was similar (74% versus 77%, P= NS). In patients with GGT normalization (versus no normalization) by 1 year, regardless of UDCA treatment status, 5-year event-free survival was better (91% versus 67%, P< 0.001). Similarly, larger reduction in GGT over 1 year (> 75% versus < 25% reduction) was also associated with improved outcome (5-year event-free survival 88% versus 61%, P= 0.005). Conclusion:A GGT < 50 and/or GGT reduction of > 75% by 1 year after PSC diagnosis predicts favorable 5-year outcomes in children. GGT has promise as a potential surrogate endpoint in future clinical trials for pediatric PSC.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Nutritional modulation of inflammation and infection

Submission date :

2019-03-01T14:07:49Z