Title :

Integrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny.

Author(s) :

Classe, Marion [Auteur]
Yao, Hui [Auteur]
Mouawad, Roger [Auteur]
Creighton Chad, J [Auteur]
Burgess, Alice [Auteur]
Allanic, Frederick [Auteur]
Wassef, Michel [Auteur]
Leroy, Xavier [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172

Verillaud, Benjamin [Auteur]
Mortuaire, Geoffrey [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center - U 995 [LIRIC]
Bielle, Franck [Auteur]
Le Tourneau, Christophe [Auteur]
Kurtz, Jean-Emmanuel [Auteur]
Khayat, David [Auteur]
Su, Xiaoping [Auteur]
Malouf Gabriel, G [Auteur]

Journal title :

Cell reports

Abbreviated title :

Cell Rep

Volume number :

25

Pages :

811-821.e5

Publication date :

2018-10-16

ISSN :

2211-1247
2211-1247

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Esthesioneuroblastoma (ENB) is a rare cancer of the olfactory mucosa, with no established molecular stratification to date. We report similarities of ENB with tumors arising in the neural crest and perform integrative ...
Show more >Esthesioneuroblastoma (ENB) is a rare cancer of the olfactory mucosa, with no established molecular stratification to date. We report similarities of ENB with tumors arising in the neural crest and perform integrative analysis of these tumors. We propose a molecular-based subtype classification of ENB as basal or neural, both of which have distinct pathological, transcriptomic, proteomic, and immune features. Among the basal subtype, we uncovered an IDH2 R172 mutant-enriched subgroup ( approximately 35%) harboring a CpG island methylator phenotype reminiscent of IDH2 mutant gliomas. Compared with the basal ENB methylome, the neural ENB methylome shows genome-wide reprogramming with loss of DNA methylation at the enhancers of axonal guidance genes. Our study reveals insights into the molecular pathogenesis of ENB and provides classification information of potential therapeutic relevance.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Submission date :

2019-03-01T14:07:54Z