High frequency of anti-protein Z antibodies in patients with anticardiolipin antibodies.

Andriamandimbisoa, Tojoniaina-Herinjaka; Kahn, Jean-Emmannuel; Bourdain, Frederic; Francois, Dominique; Vasse, Marc

Document type :

Article dans une revue scientifique

DOI :

10.1016/j.imbio.2018.08.001

PMID :

30115377

Permalink :

http://hdl.handle.net/20.500.12210/4504

Title :

High frequency of anti-protein Z antibodies in patients with anticardiolipin antibodies.

Author(s) :

Andriamandimbisoa, Tojoniaina-Herinjaka [Auteur]
Kahn, Jean-Emmannuel [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Bourdain, Frederic [Auteur]
Francois, Dominique [Auteur]
Vasse, Marc [Auteur]

Journal title :

Immunobiology

Abbreviated title :

Immunobiology

Volume number :

223

Pages :

772-776

Publication date :

2018-12

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Protein Z (PZ) is a vitamin K-dependent protein involved in the down-regulation of coagulation by forming a complex with the protein Z-dependent protease inhibitor. The complex inhibits the activated factor X on ...
Show more >Protein Z (PZ) is a vitamin K-dependent protein involved in the down-regulation of coagulation by forming a complex with the protein Z-dependent protease inhibitor. The complex inhibits the activated factor X on phospholipid surface. Presence of anti-PZ (aPZ) antibodies was first described in women with pathological pregnancies but the significance of aPZ antibodies in other pathological situations was poorly studied. In this work we analyzed the frequency of aPZ antibodies in a series of 86 consecutive patients with anticardiolipin (aCL) antibodies and studied the association of aPZ with other antiphospholipid (aPL) antibodies [lupus anticoagulant (LAC) and anti-ss2GP-1 antibodies] and the clinical signification of these aPZ antibodies in term of thrombosis or fetal loss. Anti-PZ antibodies (IgG and IgM) were detected using commercially available ELISA assays. The frequency of aPZ antibodies was 40.7% in the patient group versus 6.8% in a group of 59 healthy volunteers (p < 0.0001). The frequency of aPZ antibodies significantly increases (p < 0.05) in patients with a double or triple positivity of aPL antibodies and a higher frequency of aPZ antibodies was observed in patients with LAC (57.7%) than in patients without LAC (25.6%, p = 0.02). There were no significant differences in aPZ antibodies frequency between patients with and without thrombotic events. Interestingly, among the 8 women with recurrent foetal losses, aPZ antibodies were observed in 7 cases, in agreement with previous observations suggesting that aPZ antibodies may be associated with obstetrical complications.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Submission date :

2019-03-01T14:08:01Z
2023-11-28T06:50:09Z

Version	Link	Modification date
2	20.500.12210/4504*	2023-11-28T06:46:49Z
1	20.500.12210/4504.1	2019-03-01T14:08:01Z

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High frequency of anti-protein Z antibodies ...

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