Title :

Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study.

Author(s) :

Arouca, Aline [Auteur]
Moreno Luis, A [Auteur]
Gonzalez-Gil Esther, M [Auteur]
Marcos, Ascension [Auteur]
Widhalm, Kurt [Auteur]
Molnar, Denes [Auteur]
Manios, Yannis [Auteur]
gottrand, frederic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Kafatos, Anthony [Auteur]
Kersting, Mathilde [Auteur]
Sjostrom, Michael [Auteur]
Amaro-Gahete Francisco, Jose [Auteur]
Ferrari, Marika [Auteur]
Huybrechts, Inge [Auteur]
Gonzalez-Gross, Marcela [Auteur]
De Henauw, Stefaan [Auteur]
Michels, Nathalie [Auteur]

Journal title :

European journal of nutrition

Abbreviated title :

Eur. J. Nutr.

Publication date :

2018-06-15

ISSN :

1436-6215
1436-6215

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

AIM: Our aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers. METHODS: In 618 ...
Show more >AIM: Our aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers. METHODS: In 618 adolescents (13-17 years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake determined by a self-administered computerized 24-h recall. A 9-point Mediterranean diet score and an antioxidant-rich diet score were used as dietary parameters and tested as moderator. Total body fat was represented by the sum of six skinfold thicknesses and central adiposity by waist circumference. A set of inflammation-related biomarkers was used as outcome: a pro/anti-inflammatory interleukins ratio, TGFbeta-1, C-reactive protein, TNF-alpha, 3 cell adhesion molecules, and 3 types of immune cells; gamma-glutamyltransferase (GGT) and homocysteine were used as cardiovascular disease risk biomarkers, and alanine transaminase (ALT) as liver dysfunction biomarker. Multiple linear regression analyses tested moderation by diet in the adiposity-inflammation association and were adjusted for age, sex, country, puberty, socioeconomic status. RESULTS: Both the Mediterranean and antioxidant-rich diet, and overall and central adiposity, were important in the moderation. Diet was a significant protective moderator in the effect of adiposity on the pro/anti-inflammatory interleukins ratio, TGFbeta-1, GGT, and ALT. CONCLUSION: In conclusion, in some cases, a diet rich in antioxidants and essential nutrients may attenuate the concentration of inflammatory biomarkers caused by adiposity, whereas a poor diet appears to contribute to the onset of early oxidative stress signs.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Nutritional modulation of inflammation and infection

Submission date :

2019-03-01T14:08:04Z