Title :

A comparison of multiple sclerosis disease activity after discontinuation of fingolimod and placebo.

Author(s) :

Vermersch, Patrick [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Radue, Ernst-Wilhelm [Auteur]
Putzki, Norman [Auteur]
Ritter, Shannon [Auteur]
Merschhemke, Martin [Auteur]
Freedman Mark, S [Auteur]

Journal title :

Multiple sclerosis journal - experimental, translational and clinical

Abbreviated title :

Mult Scler J Exp Transl Clin

Volume number :

3

Pages :

2055217317730096

Publication date :

2017-01-01

ISSN :

2055-2173
2055-2173

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Cases of higher-than-expected disease activity have been reported following fingolimod discontinuation. OBJECTIVE: The objective of this paper is to assess the risk of substantially higher-than-expected ...
Show more >BACKGROUND: Cases of higher-than-expected disease activity have been reported following fingolimod discontinuation. OBJECTIVE: The objective of this paper is to assess the risk of substantially higher-than-expected disease activity post-study drug discontinuation (SDD) at the individual patient level using data from the Phase III, placebo-controlled FREEDOMS and FREEDOMS II trials. METHODS: Baseline gadolinium-enhancing T1-lesion volumes were used to statistically model the expected level of MRI disease activity post-SDD. Patients exceeding this level were classed asShow less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Submission date :

2019-03-01T14:09:32Z