Flexible Nanoholey Patches for Antibiotic-Free ...
Document type :
Compte-rendu et recension critique d'ouvrage
DOI :
Title :
Flexible Nanoholey Patches for Antibiotic-Free Treatments of Skin Infections
Author(s) :
Li, Chengnan [Auteur]
Shandong University
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Ye, Ran [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Bouckaert, Julie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Zurutuza, Amaia [Auteur]
Drider, Djamel [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Dumych, Tetiana [Auteur]
Paryzhak, Solomiya [Auteur]
Vovk, Volodymyr [Auteur]
O. Bilyy, Rostyslav [Auteur]
Melinte, Sorin [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Li, Musen [Auteur]
Shandong University
Boukherroub, Rabah [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Szunerits, Sabine [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Shandong University
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Ye, Ran [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Bouckaert, Julie [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Zurutuza, Amaia [Auteur]
Drider, Djamel [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Dumych, Tetiana [Auteur]
Paryzhak, Solomiya [Auteur]
Vovk, Volodymyr [Auteur]
O. Bilyy, Rostyslav [Auteur]
Melinte, Sorin [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Li, Musen [Auteur]
Shandong University
Boukherroub, Rabah [Auteur]

Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Szunerits, Sabine [Auteur]

Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Journal title :
ACS Applied Materials & Interfaces
Pages :
36665-36674
Publisher :
Washington, D.C. : American Chemical Society
Publication date :
2017
ISSN :
1944-8244
English keyword(s) :
bacteria ablation
polyimide
reduced graphene oxide
gold nanoholes
in vivo treatment
wound infection
photothermal therapy
polyimide
reduced graphene oxide
gold nanoholes
in vivo treatment
wound infection
photothermal therapy
HAL domain(s) :
Chimie/Chimie thérapeutique
Chimie/Matériaux
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Chimie/Matériaux
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
English abstract : [en]
Despite the availability of different antibiotics, bacterial infections are still one of the leading causes of hospitalization and mortality. The clinical failure of antibiotic treatment is due to a general poor antibiotic ...
Show more >Despite the availability of different antibiotics, bacterial infections are still one of the leading causes of hospitalization and mortality. The clinical failure of antibiotic treatment is due to a general poor antibiotic penetration to bacterial infection sites as well as the development of antibiotic-resistant pathogens. In the case of skin infection, the wound is covered by exudate, making it impermeable to topical antibiotics. The development of a flexible patch allowing a rapid and highly efficient treatment of subcutaneous wound infections via photothermal irradiation is presented here. The skin patch combines the near-infrared photothermal properties of a gold nanohole array formed by self-assembly of colloidal structures on flexible polyimide films with that of reduced graphene oxide nanosheets for laser-gated pathogen inactivation. In vivo tests performed on mice with subcutaneous skin infection and treated with the photothermal skin patch show wound healing of the infected site, while nontreated areas result in necrotic muscular fibers and bacterial infiltrate. No loss in efficiency is observed upon multiple use of these patches during in vivo experiments because of their robustness.Show less >
Show more >Despite the availability of different antibiotics, bacterial infections are still one of the leading causes of hospitalization and mortality. The clinical failure of antibiotic treatment is due to a general poor antibiotic penetration to bacterial infection sites as well as the development of antibiotic-resistant pathogens. In the case of skin infection, the wound is covered by exudate, making it impermeable to topical antibiotics. The development of a flexible patch allowing a rapid and highly efficient treatment of subcutaneous wound infections via photothermal irradiation is presented here. The skin patch combines the near-infrared photothermal properties of a gold nanohole array formed by self-assembly of colloidal structures on flexible polyimide films with that of reduced graphene oxide nanosheets for laser-gated pathogen inactivation. In vivo tests performed on mice with subcutaneous skin infection and treated with the photothermal skin patch show wound healing of the infected site, while nontreated areas result in necrotic muscular fibers and bacterial infiltrate. No loss in efficiency is observed upon multiple use of these patches during in vivo experiments because of their robustness.Show less >
Language :
Anglais
Popular science :
Non
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