Title :

Safety of Intravenous Immunoglobulin (Tegeline (R)), Administered at Home in Patients with Autoimmune Disease: Results of a French Study

Author(s) :

Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Le Masson, Gwendal [Auteur]
Sole, Guilhem [Auteur]
Hamidou, Mohamed [Auteur]
Desnuelle, Claude [Auteur]
Azulay, Jean-Philippe [Auteur]
Besson, Gerard [Auteur]
Swiader, Laure [Auteur]
Abad, Sebastien [Auteur]
Antoine, Jean-Christophe [Auteur]
Bouhour, Francoise [Auteur]
Creange, Alain [Auteur]
Grenouillet, Marike [Auteur]
Magy, Laurent [Auteur]
Marcel, Sebastien [Auteur]
Paquet, Jean-Michel [Auteur]
Rouhart, Francois [Auteur]
Ziegler, Francois [Auteur]
Mathis, Stephane [Auteur]
Gauthier-Darnis, Marc [Auteur]
Puget, Sophie [Auteur]

Journal title :

BioMed Research International

Abbreviated title :

Biomed Res. Int.

Volume number :

2018

Publication date :

2018-03-15

ISSN :

2314-6133

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The efficacy of intravenous immunoglobulins (IVIg) in patients with autoimmune diseases (AID) has been known for several decades. Majority of these patients received IVIg in hospital. A retrospective study was conducted ...
Show more >The efficacy of intravenous immunoglobulins (IVIg) in patients with autoimmune diseases (AID) has been known for several decades. Majority of these patients received IVIg in hospital. A retrospective study was conducted in 22 centers in France to evaluate the feasibility of the administration of Tegeline, an IVIg from LFB Biomedicaments, and assess its safety at home, compared to in hospital, in patients with AID. The included patients were at least 18 years old, suffering from AID, and treated with at least 1 cycle of Tegeline at home after receiving 3 consecutive cycles of hospital-based treatment with Tegeline at a dose between 1 and 2 g/kg/cycle. Forty-six patients with AID, in most cases immune-mediated neuropathies, received a total of 138 cycles of Tegeline in hospital and then 323 at home. Forty-five drug-related adverse events occurred in 17 patients who received their cycles at home compared to 24 adverse events in hospital in 15 patients. Serious adverse events occurred in 3 patients during home treatment, but they were not life-threatening and did not lead to discontinuation of Tegeline. Forty-five patients continued their treatment with Tegeline at home or in hospital; 39 (84.8%) were still receiving home treatment at the end of the study. In conclusion, the study demonstrates the good safety profile of Tegeline administered at home at high doses in patients with AID who are eligible for home administration of Tegeline.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Submission date :

2019-03-01T14:17:24Z
2024-01-25T13:43:57Z