Cost of cancer diagnosis using next-generation ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Cost of cancer diagnosis using next-generation sequencing targeted gene panels in routine practice: a nationwide French study
Auteur(s) :
Marino, Patricia [Auteur]
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
Touzani, Rajae [Auteur]
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
Perrier, Lionel [Auteur]
Centre Léon Bérard [Lyon]
Rouleau, Etienne [Auteur]
Département de biologie et pathologie médicales [Gustave Roussy]
Kossi Dede, Sika [Auteur]
Fondation Ophtalmologique Adolphe de Rothschild [Paris]
Zou, Zhaomin [Auteur]
Institut Gustave Roussy [IGR]
Charrier, Nathanael [Auteur]
Goardon, Nicolas [Auteur]
Centre Régional de Lutte contre le Cancer François Baclesse [Caen] [UNICANCER/CRLC]
Preudhomme, Claude [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Durand-Zaleski, Isabelle [Auteur]
Baffert, Sandrine [Auteur]
Fondation Ophtalmologique Adolphe de Rothschild [Paris]
Barillot, Emmanuel [Auteur]
Bezieau, Stephane [Auteur]
Borget, Isabelle [Auteur]
Institut Gustave Roussy [IGR]
Coppin, Lucie [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Descapentries, Clothilde [Auteur]
Forget, Sebastien [Auteur]
Frebourd, Thierry [Auteur]
Guardiola, Philippe [Auteur]
Houdayer, Claude [Auteur]
Hupe, Philippe [Auteur]
Lacroix, Ludovic [Auteur]
Leclerc, Julie [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Lespagnol, Alexandra [Auteur]
Longuemare, Stephanie [Auteur]
Mosser, Jean [Auteur]
Odou, Marie-Francoise [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Revillion, Francoise [Auteur]
Sevenet, Nicolas [Auteur]
Soubeyran, Isabelle [Auteur]
Vaur, Dominique [Auteur]
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
Touzani, Rajae [Auteur]
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
Perrier, Lionel [Auteur]
Centre Léon Bérard [Lyon]
Rouleau, Etienne [Auteur]
Département de biologie et pathologie médicales [Gustave Roussy]
Kossi Dede, Sika [Auteur]
Fondation Ophtalmologique Adolphe de Rothschild [Paris]
Zou, Zhaomin [Auteur]
Institut Gustave Roussy [IGR]
Charrier, Nathanael [Auteur]
Goardon, Nicolas [Auteur]
Centre Régional de Lutte contre le Cancer François Baclesse [Caen] [UNICANCER/CRLC]
Preudhomme, Claude [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Durand-Zaleski, Isabelle [Auteur]
Baffert, Sandrine [Auteur]
Fondation Ophtalmologique Adolphe de Rothschild [Paris]
Barillot, Emmanuel [Auteur]
Bezieau, Stephane [Auteur]
Borget, Isabelle [Auteur]
Institut Gustave Roussy [IGR]
Coppin, Lucie [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Descapentries, Clothilde [Auteur]
Forget, Sebastien [Auteur]
Frebourd, Thierry [Auteur]
Guardiola, Philippe [Auteur]
Houdayer, Claude [Auteur]
Hupe, Philippe [Auteur]
Lacroix, Ludovic [Auteur]
Leclerc, Julie [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Lespagnol, Alexandra [Auteur]
Longuemare, Stephanie [Auteur]
Mosser, Jean [Auteur]
Odou, Marie-Francoise [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Revillion, Francoise [Auteur]
Sevenet, Nicolas [Auteur]
Soubeyran, Isabelle [Auteur]
Vaur, Dominique [Auteur]
Titre de la revue :
European Journal of Human Genetics
Nom court de la revue :
Eur. J. Hum. Genet.
Numéro :
26
Pagination :
314-323
Date de publication :
2018-03
ISSN :
1018-4813
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
It is currently unclear if next-generation sequencing (NGS) technologies can be implemented in the diagnosis setting at an affordable cost. The aim of this study was to measure the total cost of performing NGS in clinical ...
Lire la suite >It is currently unclear if next-generation sequencing (NGS) technologies can be implemented in the diagnosis setting at an affordable cost. The aim of this study was to measure the total cost of performing NGS in clinical practice in France, in both germline and somatic cancer genetics.The study was performed on 15 French representative cancer molecular genetics laboratories performing NGS panels' tests. The production cost was estimated using a micro-costing method with resources consumed collected in situ in each laboratory from a healthcare provider perspective. In addition, we used a top-down methodology for specific post-sequencing steps including bioinformatics, technical validation, and biological validation. Additional non-specific costs were also included. Costs were detailed per step of the process (from the pre-analytical phase to delivery of results), and per cost driver (consumables, staff, equipment, maintenance, overheads). Sensitivity analyses were performed.The mean total cost of NGS for targeted gene panels was estimated to 607euro (+/-207) in somatic genetics and 550euro (+/-140) in germline oncogenetic analysis. Consumables were the highest cost driver of the sequencing process. The sensitivity analysis showed that a 25% reduction of consumables resulted in a 15% decrease in total NGS cost in somatic genetics, and 13% in germline analysis. Additional costs accounted for 30-32% of the total NGS costs.Beyond cost assessment considerations, the diffusion of NGS technologies will raise questions about their efficiency when compared to more targeted approaches, and their added value in a context of routine diagnosis.Lire moins >
Lire la suite >It is currently unclear if next-generation sequencing (NGS) technologies can be implemented in the diagnosis setting at an affordable cost. The aim of this study was to measure the total cost of performing NGS in clinical practice in France, in both germline and somatic cancer genetics.The study was performed on 15 French representative cancer molecular genetics laboratories performing NGS panels' tests. The production cost was estimated using a micro-costing method with resources consumed collected in situ in each laboratory from a healthcare provider perspective. In addition, we used a top-down methodology for specific post-sequencing steps including bioinformatics, technical validation, and biological validation. Additional non-specific costs were also included. Costs were detailed per step of the process (from the pre-analytical phase to delivery of results), and per cost driver (consumables, staff, equipment, maintenance, overheads). Sensitivity analyses were performed.The mean total cost of NGS for targeted gene panels was estimated to 607euro (+/-207) in somatic genetics and 550euro (+/-140) in germline oncogenetic analysis. Consumables were the highest cost driver of the sequencing process. The sensitivity analysis showed that a 25% reduction of consumables resulted in a 15% decrease in total NGS cost in somatic genetics, and 13% in germline analysis. Additional costs accounted for 30-32% of the total NGS costs.Beyond cost assessment considerations, the diffusion of NGS technologies will raise questions about their efficiency when compared to more targeted approaches, and their added value in a context of routine diagnosis.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Collections :
Équipe(s) de recherche :
Inflammatory digestive disease : pathophysiology and therapeutic targets developement
Date de dépôt :
2019-03-01T14:17:25Z
2021-05-14T08:21:26Z
2024-03-05T09:11:04Z
2021-05-14T08:21:26Z
2024-03-05T09:11:04Z