Title :

Long-term quality of life in adult patients surviving purpura fulminans: an exposed-unexposed multicenter cohort study.

Author(s) :

Contou, Damien [Auteur]
Université Paris-Est Créteil Val-de-Marne - Paris 12 [UPEC UP12]
Canoui-Poitrine, Florence [Auteur]
Université Paris-Est [UPE]
Coudroy, Remi [Auteur]
Preau, Sebastien [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Lille Inflammation Research International Center (LIRIC) - U995
Cour, Martin [Auteur]
Barbier, Francois [Auteur]
Terzi, Nicolas [Auteur]
Schnell, Guillaume [Auteur]
Galbois, Arnaud [Auteur]
Zafrani, Lara [Auteur]
Zuber, Benjamin [Auteur]
Ehrmann, Stephan [Auteur]
Gelisse, Elodie [Auteur]
Colling, Delphine [Auteur]
Schmidt, Matthieu [Auteur]
Jaber, Samir [Auteur]
Conia, Alexandre [Auteur]
Sonneville, Romain [Auteur]
Colin, Gwenhael [Auteur]
Guerin, Laurent [Auteur]
Roux, Damien [Auteur]
Jochmans, Sebastien [Auteur]
Kentish-Barnes, Nancy [Auteur]
Audureau, Etienne [Auteur]
Université Paris-Est [UPE]
Layese, Richard [Auteur]
Université Paris-Est [UPE]
Alves, Aline [Auteur]
Ouedraogo, Rachida [Auteur]
Brun-Buisson, Christian [Auteur]
Mekontso Dessap, Armand [Auteur]
Université Paris-Est Créteil Val-de-Marne - Paris 12 [UPEC UP12]
De Prost, Nicolas [Auteur]
Université Paris-Est Créteil Val-de-Marne - Paris 12 [UPEC UP12]

Journal title :

Clinical Infectious Diseases

Abbreviated title :

Clin. Infect. Dis.

Volume number :

69

Pages :

332–340

Publication date :

2019-07

ISSN :

1537-6591

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background: Long-term Health-related Quality of Life (HR-QOL) of patients surviving the acute phase of purpura fulminans (PF) has not been evaluated. Methods: A French multicenter exposed-unexposed cohort study enrolling ...
Show more >Background: Long-term Health-related Quality of Life (HR-QOL) of patients surviving the acute phase of purpura fulminans (PF) has not been evaluated. Methods: A French multicenter exposed-unexposed cohort study enrolling patients admitted in 55 ICUs for a PF from 2010 to 2016. Adult patients surviving the acute phase of PF (exposed group) were matched 1:1 for age, SAPS II and gender with septic shock survivors (unexposed group). HR-QOL was assessed during a phone-interview using the SF-36 questionnaire, the Hospital Anxiety and Depression (HAD) scale, the Impact of Event Scale-Revised (IES-R) and the Activity of Daily Living (ADL) and Instrumental ADL (IADL) scales. The primary outcome measure was the physical component summary (PCS) of the SF-36 questionnaire. Results: Thirty-seven survivors of PF and 37 of septic shock were phone-interviewed at 55 [35-83] and 44 [35-72] months of ICU discharge, respectively (p=0.23). The PCS of the SF-36 was not significantly different between exposed and unexposed patients (median [quartile1-quartile3]=47 [36-53] vs. 54 [36-57]; p=0.18). There was also no significant difference between groups regarding the mental component summary of the SF-36, and the HAD, IES-R, ADL and IADL scales. Among the 37 exposed patients, those who required limb amputation (n=12/37, 32%) exhibited lower PCS (34 [24-38] vs. 52 [42-56]; p=0.001) and IADL scores (7 [4-8] vs. 8 [7-8]; p=0.021) as compared to non-amputated patients. Conclusion: Long-term HR-QOL does not differ between patients surviving PF and those surviving septic shock unrelated to PF. Amputated patients have an impaired physical HR-QOL but a preserved mental health. Clinical Trials: NCT03216577.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Glycation from inflammation to aging

Submission date :

2019-03-01T14:17:35Z
2024-03-04T09:56:36Z