Title :

Overall survival and mortality risk factors in Takayasu''s arteritis: A multicenter study of 318 patients.

Author(s) :

Mirouse, Adrien [Auteur]
Biard, Lucie [Auteur]
Comarmond, Cloe [Auteur]
Lambert, Marc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Mekinian, Arsene [Auteur]
Ferfar, Yasmina [Auteur]
Kahn, Jean-Emmannuel [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Benhamou, Ygal [Auteur]
Chiche, Laurent [Auteur]
Koskas, Fabien [Auteur]
Cluzel, Philippe [Auteur]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Messas, Emmanuel [Auteur]
Cacoub, Patrice [Auteur]
Mirault, Tristan [Auteur]
Resche-Rigon, Matthieu [Auteur]
Saadoun, David [Auteur]

Journal title :

Journal of autoimmunity

Abbreviated title :

J. Autoimmun.

Publication date :

2018-08-16

ISSN :

1095-9157

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: To report the long term mortality in Takayasu arteritis (TA) and to identify prognosis factors. METHODS: We analyzed the causes of death and the factors associated with mortality in a cohort of 318 patients ...
Show more >OBJECTIVE: To report the long term mortality in Takayasu arteritis (TA) and to identify prognosis factors. METHODS: We analyzed the causes of death and the factors associated with mortality in a cohort of 318 patients [median age at diagnosis was 36 [25-47] years and 276 (86%) patients were women] fulfilling American College of Rheumatology and/or Ishikawa criteria of TA. A prognostic score for death and vascular complications was elaborated based on a multivariate model. RESULTS: Among 318TA patients, 16 (5%) died after a median [IQR] follow-up of 6.1 [2.8-13.0] years. The median age at death was 38 [25-47] years with 88% of women. Main causes of death included mesenteric ischemia (n=4, 25%) and aortic aneurysm rupture (n=4, 25%). The mortality rate at 5 and 10 years was of 1.9% and 3.9%, respectively. Caucasians (p=0.049) and smokers (p=0.002) TA patients were more likely to die. There was an increased mortality in TA (SMR with 95% confidence interval, 2.73 [1.69-4.22]) as compared to age and sex matched healthy controls. We defined high risk patients for death and vascular complications according to the presence of two of the following factors (i.e a progressive clinical course, thoracic aorta involvement and/or retinopathy). In the high risk TA group, the 5-year incidence of death and vascular complication was 48.5% compared to 21.6% (p=0.001) in those with low risk. CONCLUSION: The overall mortality in our Takayasu cohort was 5% after a median follow-up of 6.1 years. We identified specific characteristics that distinguish TA patients at highest risk for death and vascular complications.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Immunity, inflammation and fibrsis in auto and allo-reactivity
Glycation from inflammation to aging

Submission date :

2019-03-01T14:17:41Z