Title :

In silico validation of the Autoinflammatory Disease Damage Index.

Author(s) :

Ter Haar Nienke, M [Auteur]
Van Delft Amber Laetitia, Justine [Auteur]
Annink Kim, Valerie [Auteur]
Van Stel, Henk [Auteur]
Al-Mayouf Sulaiman, M [Auteur]
Amaryan, Gayane [Auteur]
Anton, Jordi [Auteur]
Barron Karyl, S [Auteur]
Benseler, Susanne [Auteur]
Brogan Paul, A [Auteur]
Cantarini, Luca [Auteur]
Cattalini, Marco [Auteur]
Cochino, Alexis-Virgil [Auteur]
De Benedetti, Fabrizio [Auteur]
Dedeoglu, Fatma [Auteur]
De Jesus Adriana, Almeida [Auteur]
Demirkaya, Erkan [Auteur]
Dolezalova, Pavla [Auteur]
Durrant Karen, L [Auteur]
Fabio, Giovanna [Auteur]
Gallizzi, Romina [Auteur]
Goldbach-Mansky, Raphaela [Auteur]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Hentgen, Veronique [Auteur]
Herlin, Troels [Auteur]
Hofer, Michael [Auteur]
Hoffman Hal, M [Auteur]
Insalaco, Antonella [Auteur]
Jansson Annette, F [Auteur]
Kallinich, Tilmann [Auteur]
Kone-Paut, Isabelle [Auteur]
Kozlova, Anna [Auteur]
Kuemmerle-Deschner Jasmin, Beate [Auteur]
Lachmann Helen, J [Auteur]
Laxer Ronald, M [Auteur]
Martini, Alberto [Auteur]
Nielsen, Susan [Auteur]
Nikishina, Irina [Auteur]
Ombrello Amanda, K [Auteur]
Ozen, Seza [Auteur]
Papadopoulou-Alataki, Efimia [Auteur]
Quartier, Pierre [Auteur]
Rigante, Donato [Auteur]
Russo, Ricardo [Auteur]
Simon, Anna [Auteur]
Trachana, Maria [Auteur]
Uziel, Yosef [Auteur]
Ravelli, Angelo [Auteur]
Schulert, Grant [Auteur]
Gattorno, Marco [Auteur]
Frenkel, Joost [Auteur]

Journal title :

Annals of the rheumatic diseases

Abbreviated title :

Ann. Rheum. Dis.

Publication date :

2018-08-04

ISSN :

1468-2060

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

INTRODUCTION: Autoinflammatory diseases can cause irreversible tissue damage due to systemic inflammation. Recently, the Autoinflammatory Disease Damage Index (ADDI) was developed. The ADDI is the first instrument to ...
Show more >INTRODUCTION: Autoinflammatory diseases can cause irreversible tissue damage due to systemic inflammation. Recently, the Autoinflammatory Disease Damage Index (ADDI) was developed. The ADDI is the first instrument to quantify damage in familial Mediterranean fever, cryopyrin-associated periodic syndromes, mevalonate kinase deficiency and tumour necrosis factor receptor-associated periodic syndrome. The aim of this study was to validate this tool for its intended use in a clinical/research setting. METHODS: The ADDI was scored on paper clinical cases by at least three physicians per case, independently of each other. Face and content validity were assessed by requesting comments on the ADDI. Reliability was tested by calculating the intraclass correlation coefficient (ICC) using an 'observer-nested-within-subject' design. Construct validity was determined by correlating the ADDI score to the Physician Global Assessment (PGA) of damage and disease activity. Redundancy of individual items was determined with Cronbach's alpha. RESULTS: The ADDI was validated on a total of 110 paper clinical cases by 37 experts in autoinflammatory diseases. This yielded an ICC of 0.84 (95% CI 0.78 to 0.89). The ADDI score correlated strongly with PGA-damage (r=0.92, 95% CI 0.88 to 0.95) and was not strongly influenced by disease activity (r=0.395, 95% CI 0.21 to 0.55). After comments from disease experts, some item definitions were refined. The interitem correlation in all different categories was lower than 0.7, indicating that there was no redundancy between individual damage items. CONCLUSION: The ADDI is a reliable and valid instrument to quantify damage in individual patients and can be used to compare disease outcomes in clinical studies.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Submission date :

2019-03-01T14:17:43Z