Title :

Long-term risk of solid organ de novo malignancies after liver transplantation: a French national study on 11226 patients.

Author(s) :

Seree, Olivier [Auteur]
Altieri, Mario [Auteur]
Guillaume, Elodie [Auteur]
De Mil, Remy [Auteur]
Lobbedez, Thierry [Auteur]
Université de Caen Normandie [UNICAEN]
Robinson, Philip [Auteur]
Segol, Philippe [Auteur]
Salame, Ephrem [Auteur]
Abergel, Armand [Auteur]
Boillot, Olivier [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Conti, Filomena [Auteur]
Chazouilleres, Olivier [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Debette-Gratien, Maryline [Auteur]
Université de Limoges [UNILIM]
Debray, Dominique [Auteur]
Hery, Geraldine [Auteur]
Dharancy, Sebastien [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Durand, Francois [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Duvoux, Christophe [Auteur]
Francoz, Claire [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Gugenheim, Jean [Auteur]
Université de Nice Sophia-Antipolis [UNSA]
Hardwigsen, Jean [Auteur]
Houssel-Debry, Pauline [Auteur]
Jacquemin, Emmanuel [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Kamar, Nassim [Auteur]
Latournerie, Marianne [Auteur]
Université de Bourgogne [UB]
Lebray, Pascal [Auteur]
Leroy, Vincent [Auteur]
Université Grenoble Alpes [2016-2019] [UGA [2016-2019]]
Mazzola, Alessandra [Auteur]
Neau-Cransac, Martine [Auteur]
Pageaux, Georges-Philippe [Auteur]
Radenne, Sylvie [Auteur]
Saliba, Faouzi [Auteur]
Samuel, Didier [Auteur]
Vanlemmens, Claire [Auteur]
Woehl-Jaegle, Marie-Lorraine [Auteur]
Launoy, Guy [Auteur]
Dumortier, Jerome [Auteur]
Université Claude Bernard Lyon 1 [UCBL]

Journal title :

Liver Transplantation

Abbreviated title :

Liver Transpl.

Volume number :

24

Pages :

1425-1436

Publication date :

2018-10

ISSN :

1527-6473

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

De novo malignancies are one of the major late complications and causes of death after liver transplantation (LT). Using extensive data from the French national Agence de la Biomedecine database, the present study aimed ...
Show more >De novo malignancies are one of the major late complications and causes of death after liver transplantation (LT). Using extensive data from the French national Agence de la Biomedecine database, the present study aimed to quantify the risk of solid organ de novo malignancies (excluding nonmelanoma skin cancers) after LT. The incidence of de novo malignancies among all LT patients between 1993 and 2012 was compared with that of the French population, standardized on age, sex, and calendar period (standardized incidence ratio; SIR). Among the 11,226 LT patients included in the study, 1200 de novo malignancies were diagnosed (10.7%). The risk of death was approximately 2 times higher in patients with de novo malignancy (48.8% versus 24.3%). The SIR for all de novo solid organ malignancies was 2.20 (95% confidence interval [CI], 2.08-2.33). The risk was higher in men (SIR = 2.23; 95% CI, 2.09-2.38) and in patients transplanted for alcoholic liver disease (ALD; SIR = 2.89; 95% CI, 2.68-3.11). The cancers with the highest excess risk were laryngeal (SIR = 7.57; 95% CI, 5.97-9.48), esophageal (SIR = 4.76; 95% CI, 3.56-6.24), lung (SIR = 2.56; 95% CI, 2.21-2.95), and lip-mouth-pharynx (SIR = 2.20; 95% CI, 1.72-2.77). In conclusion, LT recipients have an increased risk of de novo solid organ malignancies, and this is strongly related to ALD as a primary indication for LT.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Inflammatory digestive disease : pathophysiology and therapeutic targets developement

Submission date :

2019-03-01T14:17:45Z
2024-01-30T10:01:32Z