Title :

Influence of Percutaneous Endoscopic Gastrostomy on Gastroesophageal Reflux Disease in Children.

Author(s) :

Aumar, Madeleine [Auteur]
Lalanne, Arnaud [Auteur]
Guimber, Dominique [Auteur]
Coopman, Stephanie [Auteur]
Turck, Dominique [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Michaud, Laurent [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
gottrand, frederic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

The Journal of pediatrics

Abbreviated title :

J. Pediatr.

Publication date :

2018-04-11

ISSN :

1097-6833

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: To determine if gastroesophageal reflux disease (GERD) is present at long-term follow-up after percutaneous endoscopic gastrostomy (PEG), and to identify factors associated with the occurrence or aggravation ...
Show more >OBJECTIVE: To determine if gastroesophageal reflux disease (GERD) is present at long-term follow-up after percutaneous endoscopic gastrostomy (PEG), and to identify factors associated with the occurrence or aggravation of GERD after PEG placement. STUDY DESIGN: This prospective, observational study was conducted in our single tertiary center over a 13-year period (gastrostomy performed from 1990 to 2003 and follow-up to 2015). Every child who underwent PEG in our center (N = 368) from 1990 to 2003 was eligible. GERD was defined by clinical manifestations requiring antisecretory or prokinetic treatment, occurrence of a GERD-related complication, or the need for antireflux surgery. Outcomes among patients without antireflux surgery were also assessed. Multivariate analysis was used to identify factors aggravating GERD after PEG placement. RESULTS: A total 326 patients (89%; 56% with a neurologic impairment) were studied with a median follow-up after 3.5 years (range, 2.0-13.5 years). After PEG placement, GERD appeared in 11% of patients and was aggravated in 25% of patients with preexisting GERD. Factors associated with GERD worsening after PEG placement were neurologic impairment and preexisting GERD. Only 53 patients (16%) required antireflux surgery, among whom 22 required surgery in the year after PEG. Neurologic impairment was the only factor significantly associated with the need for antireflux surgery. CONCLUSIONS: GERD predominantly remains clinically controlled after PEG placement. Routine antireflux surgery at the time of PEG placement is not justified.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Nutritional modulation of inflammation and infection

Submission date :

2019-03-01T14:17:52Z